نتایج جستجو برای: auto antigen
تعداد نتایج: 226878 فیلتر نتایج به سال:
The acknowledgement of risks for traumatic brain injury in American football players has prompted studies for sideline concussion diagnosis and testing for neurological deficits. While concussions are recognized etiological factors for a spectrum of neurological sequelae, the consequences of sub-concussive events are unclear. We tested the hypothesis that blood-brain barrier disruption (BBBD) a...
Background: Auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) may be central to the pathogenesis of adult sporadic pulmonary alveolar proteinosis (PAP). The role of antiGM-CSF auto-antibodies in paediatric forms of PAP is as yet unclear. Methods: Anti-GM-CSF auto-antibodies were determined with the help of an antigen capture assay using serum and/or bronchoalveol...
To prevent life-threatening auto-inflammation/auto-immunity in peripheral tissue such as skin, the immune system must simultaneously mount rapid protective immunity, and rapidly resolve inflammation. Dendritic Cells (DC), are highly abundant skin other tissues, mediate tolerance, confer vaccine, tumor, infectious immunity by priming T cells. Like myeloid cells, DC differentiate from bone marrow...
Abstract Mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with chronic antigen stimulation: auto-antigens or of microbial origin. Only one study suggested association between Achromobacter xylosoxidans and pulmonary MALT lymphoma. We aimed to investigate the presence virus any infectious agents in by using metagenomic next-generation sequencing (mNGS). All lung samples ...
BACKGROUND Auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) may be central to the pathogenesis of adult sporadic pulmonary alveolar proteinosis (PAP). The role of anti-GM-CSF auto-antibodies in paediatric forms of PAP is as yet unclear. METHODS Anti-GM-CSF auto-antibodies were determined with the help of an antigen capture assay using serum and/or bronchoalveo...
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We here describe a novel application of cytotoxic saporin-conjugated tetramers to kill antigen-specific...
In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS h...
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