Benign recurrent intrahepatic cholestasis (BRIC) is a rare genetic disorder that characterized by episodes of followed complete resolution. The episodic nature BRIC raises concerns about its possible trigger factors. Indeed, case reports this orphan disease have associated to some triggers. In the absence any reviews, we reviewed factors and pathophysiology. study consisted systematic search fo...

Schizosaccharomyces pombe cdc15 homology (PCH) family members participate in many cellular processes by bridging the plasma membrane and cytoskeleton. Their F-BAR domains bind and curve membranes, whereas other domains, typically SH3 domains, are expected to provide cytoskeletal links. We tested this prevailing model of functional division in the founding member of the family, Cdc15, which is e...

Liver is the major organ that eliminates xenobiotics from the body, a process that is accomplished by a series of drug-processing genes (DPGs). These genes encode transporters on both basolateral and apical membranes of hepatocytes, as well as phase I and II enzymes. The current study compares the expression of hepatic DPGs in adult and aged mouse livers and explores the potential effects of en...