BACKGROUND Serotonin, a key denominator of the brain-gut axis, is involved in the regulation of gastrointestinal motility, secretion, and perception as well as cognition and mood. AIM To assess the effects of an acutely lowered serotonin synthesis, using the acute tryptophan depletion (ATD) method, on visceral perception, affective memory performance, and mood in diarrhoea predominant irritab...

Antithyroid drugs (ATDs) have been shown to attenuate the effectiveness of radioiodine (radioiodine ablation, RIA) therapy in Graves' disease. We undertook a study to look at the impact of iodine uptakes on the outcome of (131)I therapy. To determine the effect of prior ATD use on the duration of time to achieve cure in patients with high vs intermediate uptake Graves' disease who received a fi...

CONTEXT Neutropenia secondary to antithyroid drug (ATD) therapy in Graves' disease (GD) is well recognized. However, the effect of hyperthyroidism, prior to and after ATD therapy, on neutrophil counts in patients with GD is unclear. OBJECTIVE To study the prevalence of neutropenia in newly diagnosed untreated GD and the effect of ATD on the neutrophil count. DESIGN Prospective study from Au...

The Hybrid III 50th percentile male anthropomorphic test device (ATD) is the most widely used human impact testing surrogate and has historically been used in automotive or military testing. More recently, this ATD is finding use in applications evaluating athletic helmet protectivity, quantifying head impact dosage and estimating injury risk. But ATD head-neck response has not been quantified ...

BACKGROUND Activation of the type I interferon (IFN) pathway has been implicated in the pathogenesis of systemic autoimmune disorders but its role in the pathogenesis of organ-specific autoimmunity is limited. We tested the hypothesis that endogenous expression of type I IFN functional activity contributes to the pathogenesis of autoimmune thyroid disease (ATD) and type I diabetes (T1DM). MET...

Serotonin (5-hydroxytryptamine, 5-HT) is known to play a role in a wide variety of functions including: mood, anxiety, sleep, aggression, sexual function and cognitive function. In the past decade, the sudden interest in acute amino acid depletion paradigms has stimulated the interest in studying the function of 5-HT in man in vivo. In particular, investigating the association of experimentally...

Zinc is vastly present in the mammalian brain and controls functions of various cell surface receptors to regulate neurotransmission. A distinctive characteristic of N-methyl-D-aspartate (NMDA) receptors containing a GluN2A subunit is that their ion channel activity is allosterically inhibited by a nano-molar concentration of zinc that binds to an extracellular domain called an amino-terminal d...

The additive turbulent decomposition (ATD) method is a computational scheme for solving the Navier–Stokes equations and related nonlinear dissipative evolution equations. It involves a decomposition of the Navier–Stokes equation into equations for largeand small-scale components similar in spirit, but different in details, to the nonlinear Galerkin methods proposed by Temam and coworkers. In th...

National Journal of Clinical Anatomy Abstract Background: Dermatoglyphics, the scientific study of the origin, development and variation of dermal ridges and patterns on the fingers, palms and soles have been employed to observe association with many congenital defects and genetic diseases. Congenital deafness refers to a hearing loss which is believed to have been present since birth. A congen...

BACKGROUND Predictors of antiplatelet therapy discontinuation (ATD) during the first year after drug-eluting stent implantation are poorly known. METHODS AND RESULTS This was a prospective study with 3-, 6-, 9-, and 12-month follow-up of patients receiving at least 1 drug-eluting stent between January and April 2008 in 29 hospitals. Individual- and hospital-level predictors of ATD were assess...