Computational full-atom models of the agonist lipopolysaccharide (LPS)-bound Toll-like receptor 4 (TLR4) embedded into a realistic plasma membrane reveal dynamic functional and structural insights TLR4 activation signaling across membrane, ectodomain bouncing movement, dimerization patterns (symmetric asymmetric) intracellular Toll/interleukin-1 (TIR) domain. These studies unveil molecular aspe...

It is well-established that native plasma membranes are characterized by an asymmetric distribution of charged (anionic) lipids across the membrane. To clarify how the asymmetry can affect membrane electrostatics, we have performed extensive atomic-scale molecular dynamics simulations of asymmetric lipid membranes composed of zwitterionic (phosphatidylcholine (PC) or phosphatidylethanolamine (P...

Asymmetric cell division is an evolutionarily conserved process that gives rise to daughter cells with different fates. In one-cell stage C. elegans embryos, this process is accompanied by asymmetric spindle positioning, which is regulated by anterior-posterior (A-P) polarity cues and driven by force generators located at the cell membrane. These force generators comprise two Gα proteins, the c...

As plasma membranes of animal cells are known to be asymmetric, the transmembrane lipid asymmetry, being essential for many membranes' properties and functions, should be properly accounted for in model membrane systems. In this paper, we employ atomic-scale molecular dynamics simulations to explore electroporation phenomena in asymmetric model membranes comprised of phosphatidylcholine (PC) an...

For the first time, a tubular asymmetric ceramic-carbonate dual phase membrane was prepared by a centrifugal casting technique and used for high temperature CO2 separation. This membrane shows high CO2 permeation flux and permeance.