Pushkaramooladi choorna was tried clinically in Tamaka shvasa  (Bronchial asthma) for a period of 45 days in concecutive 3 followups. The clinical, labortary and pulmonary function tests carried out show significant antiasthmatic effect.

Pharmacognosy Research,2023,15,2,384-391.DOI:10.5530/pres.15.2.041Published:February 2023Type:Original Article Authors:Pooja Boora, Richa Puri, Sushila Rani, Monika Mehta, and Dechan Angmo Author(s) affiliations:Pooja Boora*, Department of Botany, Panjab University, Chandigarh, INDIA. Abstract:Background: Asthma is a very common chronic disease in which there an inflammation the lungs. Inflamma...

Interleukin-5 (IL-5) is known to play a major role in the growth, differentiation, recruitment, and activation of eosinophils. The authors review the efficacy and safety of two IL-5-targeting agents used in the treatment of eosinophilic asthma.

Mepolizumab (Nucala) for severe eosinophilic asthma.

Airway remodeling is a main pathological characteristic of asthma, and strongly associated with migration and proliferation of airway smooth muscle cells. E-prostanoid (EP) receptor can regulate airway remodeling. This study established a rat model of asthma and evaluated EP changes in airway smooth muscle cells under the asthmatic state so as to provide theoretical evidence for developing EP d...

The ability of Notch signaling to regulate T helper cell development and differentiation has been widely accepted. Fringe, O-fucose-β1,3-N-acetylglucosaminyltransferases modulate Notch receptor expression and promote the Notch signaling pathway through receptor-ligand binding. In this study, we assayed the expression levels of three Fringe homologs in naive CD4(+)T cells in asthmatic rats. We f...

BackgroundAsthma is the most chronic inflammatory disorder of the airways in children and asthmatic patients can experience cardiac dysfunction, pulmonary hypertension and finally cor pulmonale later in life. We aimed to investigate Right Ventricular (RV) functions in asthmatic children by conventional and tissue Doppler echocardiography (TDE).Materials and Methods Pulmonary function tests, con...

Background: TGF-? 1 is a key cytokine involved in both airway inflammation and remodeling asthma because of its anti-inflammatory profibrotic effect. In our previous study, we found that knockdown cytosolic ?-catenin alleviated the profibrogenic effect without influencing However, exact role targeting not yet fully demonstrated. present investigated mechanism OVA-challenged asthmatic rats with ...