Background According to recent studies cutaneous manifestations to non-steroidal anti-inflammatory drugs (NSAID) may affect 0.3% of general population and the prevalence of aspirin hypersensitivity is as high as 27-35% in patients with chronic urticaria (CU). NSAID may be the cause of acute urticaria but in CU patients it usually exacerbates the disease by inhibition of the cyclooxygenase, whic...

There are currently no diagnostic methods in vitro for aspirin-induced chronic urticaria (AICU) except for the provocation test in vivo. To identify disease markers for AICU, we investigated the single nucleotide polymorphism (SNP) of the promoter loci of high-affinity IgE receptor (FcεRIα) and CD203c expression level in Chinese patients with AICU. We studied two genotypic and allelic frequenci...

Titanium plane screw fixation of the frontal sinus is an approach used by otolaryngologists to obliterate this space in an attempt to reduce sinus infections. In this case, however, the titanium used became a nidus of infection which cultured the fungus Paecilomyces. The patient also had a hypersensitivity reaction to mold with positive skin tests and IgE, as well as eosinophilic esophagitis. T...

Unraveling the Radial Paradox Michel R. Le May, MD; George A. Wells, PhD · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · e004865 Rapid Desensitization of the Patients With Aspirin Hypersensitivity and Coronary Artery Disease Udaya S. Tantry, PhD; Paul A. Gurbel, MD · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·...

BACKGROUND The oral provocation test (OPT) is the current gold standard to diagnose aspirin hypersensitivity syndrome although it is time-consuming and contains some systemic risks. Other reliable methods with lower side effects and shorter test duration are being investigated. OBJECTIVE The purpose of this study was to evaluate the efficacy of the nasal provocation test (NPT) and the basophi...

BACKGROUND: Low-dose macrolides (LDM) are anti-inflammatory agents with antineutrophilic activity, but patient selection for LDM therapy in treating chronic rhinosinusitis (CRS) is controversial. This study aimed to assess factors which predict responders. METHODOLOGY: A prospective cohort was performed. Patients CRS received roxithromycin (150 mg) once daily 12 weeks. Nasal secretions and sero...

Although acetylsalicylic acid is prescribed for a broad range of diseases, it can induce a wide array of clinically recognized hypersensitivity reactions, including aspirin-intolerant asthma (AIA) with rhinitis and aspirin-intolerant urticaria (AIU) with anaphylaxis. Altered eicosanoid metabolism is the generally accepted mechanism of aspirin intolerance; the overproduction of cysteinyl leucotr...