Background—Different blood pressure (BP)–lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP. The Conduit Artery Function Evaluation (CAFE) study, a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), examined the impact of 2 different BP lowering-regimens (atenolol thiazide-based versus am...

BACKGROUND Different blood pressure (BP)-lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP. The Conduit Artery Function Evaluation (CAFE) study, a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), examined the impact of 2 different BP lowering-regimens (atenolol+/-thiazide-based versus ...

Background The ASCOT-Carer is a self-report instrument designed to measure social care-related quality of life (SCRQoL). This article presents the psychometric testing and validation of the ASCOT-Carer four response-level interview (INT4) in a sample of unpaid carers of adults who receive publicly funded social care services in England. Methods Unpaid carers were identified through a survey of ...

BACKGROUND The mechanisms by which hypertension causes vascular events are unclear. Guidelines for diagnosis and treatment focus only on underlying mean blood pressure. We aimed to reliably establish the prognostic significance of visit-to-visit variability in blood pressure, maximum blood pressure reached, untreated episodic hypertension, and residual variability in treated patients. METHODS...

  Abstract   Background: In this study we aimed to examine the discrimination and calibration of   a severity characterization of trauma (ASCOT) in our setting to determine whether its usage   is appropriate to predict outcome of our trauma patients.   Methods: This study was conducted in three hospitals. All patients admitted in studied   hospitals were divided randomly into two equal subgroup...

Background: Premature ovarian insufficiency (POI) is a condition where the ovary loses its normal reproductive potential earlier than 40 years, compromising fertility. There no treatment for POI, only ovum or embryo donation. Autologous stem cell transplant (ASCOT) may be procedure that creates new eggs in ovaries of women with POI. The aim study was to find out efficacy ASCOT patients sufferin...

Abstract Purpose The Adult Social Care Outcomes Toolkit for informal carers (ASCOT-Carer) can be used to assess long-term care-related quality of life (LTC-QoL) adult persons using LTC services. ASCOT-Carer instrument has been translated into several languages, but preference weights reflecting the relative importance different outcome states are only available England so far. In this paper, we...