Recent development of molecular imaging probes for fluorescence-guided surgery has shown great progresses for determining tumor margin to execute the tissue resection. Here we synthesize the fluorescent gold nanoparticles conjugated with diatrizoic acid and nucleolin-targeted AS1411 aptamer. The nanoparticle conjugates exhibit high water-solubility, good biocompatibility, visible fluorescence a...

Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana en bilinen özellikleridir. Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur. G-quadruplex'in çeşitli ligandlarla stabilizasyonu veya destabilizasyonu, hücre proliferasyonunda bozulmalara olabilir. Dolayısıyla, bu ikincil yapının destabilizasyonu önemli antikanser ilaç hedefleridir. Bu çalışmada, Bismarck k...

Abstract Conventional chemotherapy used against cancer is mostly limited due to their non-targeted nature, affecting normal tissue and causing undesirable toxic effects the affected tissue. With aim of improving these treatments both therapeutically in terms safety, numerous studies are currently being carried out using nanoparticles (NPs) as a vector combining tumor targeting carrying therapeu...