V-ATPases are large, complex enzymes responsible for acidification of many internal compartments in eukaryotic cells. They also occur on plasma membranes of specialized cells, where they acidify the surrounding milieu. Numerous physiological processes depend on the activity of V-ATPases, and V-ATPases are implicated as a contributing factor in multiple diseases, including osteoporosis, deafness...

let g = (v, e) be a simple graph. hosoya polynomial of g isd(u,v)h(g, x) = {u,v}v(g)x , where, d(u ,v) denotes the distance between vertices uand v. as is the case with other graph polynomials, such as chromatic, independence anddomination polynomial, it is natural to study the roots of hosoya polynomial of a graph. inthis paper we study the roots of hosoya polynomials of some specific graphs.

Modification of the histone proteins that form the core around which chromosomal DNA is looped has profound epigenetic effects on the accessibility of the associated DNA for transcription, replication and repair. The SET domain is now recognized as generally having methyltransferase activity targeted to specific lysine residues of histone H3 or H4. There is considerable sequence conservation wi...

In December 1774, seventeen-year-old Carl August, Prince of Saxe Weimar, met the celebrated young author Johann Wolfgang Goethe in a Frankfurt hotel room. The meeting was cordial, indeed the two men got along together so splendidly that, less than a year later, Goethe accepted the prince’s invitation to move to Weimar, where he would spend the rest of his long and incredibly productive life. I ...

A failure to build solid letter-speech sound associations may contribute to reading impairments in developmental dyslexia. Whether this reduced neural integration of letters and speech sounds changes over time within individual children and how this relates to behavioral gains in reading skills remains unknown. In this research, we examined changes in event-related potential (ERP) measures of l...

In plants, as in animals, the core mechanism to retain rhythmic gene expression relies on the interaction of multiple feedback loops. In recent years, molecular genetic techniques have revealed a complex network of clock components in Arabidopsis. To gain insight into the dynamics of these interactions, new components need to be integrated into the mathematical model of the plant clock. Our app...