signal regulatory proteins (sirp) belong to immunoglobulin super family (igsf) and relate to integrin signaling cascades. it has been shown that sirpa is expressed in a variety of cells including myeloid cells and neurons. in the present study the expression of this igsf member in articular chondrocytes was investigated. methods: using a panel of anti-sirpalpha antibodies, immunohistochemistry,...

Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...

BACKGROUND Bupivacaine and supraphysiologic temperature can independently reduce cell viability of articular chondrocytes. In combination, these 2 deleterious factors could further impair cell viability. HYPOTHESIS Hyaluronan may protect chondrocytes from death induced by bupivacaine at supraphysiologic temperatures. STUDY DESIGN Controlled laboratory study. METHODS Bovine articular chond...

BACKGROUND The histologic appearance of the repair tissue after articular cartilage resurfacing procedures in humans is not well documented. HYPOTHESIS The histologic and immunohistochemical appearance of the repair tissues in failed articular cartilage resurfacing procedures will be similar, regardless of the procedure that was done, and will not resemble normal articular cartilage. STUDY ...

BACKGROUND Celecoxib has a positive effect on human osteoarthritic cartilage, but the mechanisms remain unclear. The aim of this study was to test whether celecoxib could inhibit the apoptosis of chondrocyte and ameliorate type II collagen synthesis to relieve symptoms of OA (osteoarthritis). MATERIAL/METHODS 130 Wistar rats were randomly divided into 4 groups as celecoxib (CE), ibuprofen (IB...

PURPOSE The aim of this study was to assess the potential detrimental effects of the operating room environment on exposed healthy articular cartilage and to evaluate tissue hydration treatment strategies for preserving chondrocyte viability and extracellular matrix composition in this environment. METHODS With institutional Animal Care and Use Committee approval, femoral and tibial condyles ...

Articular cartilage is a heterogeneous soft tissue that dissipates and distributes loads in mammalian joints. Though robust, cartilage is susceptible to damage from loading at high rates or magnitudes. Such injurious loads have been implicated in degenerative changes, including chronic osteoarthritis (OA), which remains a leading cause of disability in developed nations. Despite decades of rese...

Since Leidy's experiment," numerous investigations have been made of the changes occurring in mature articular cartilage experimentally traumatized by incision.' Although one of the frequently described changes was an increase in the number of chondrocytes occurring at or near the site of injury, only two investigators"'8 reported finding chondrocytes undergoing mitotic division. These results ...