BACKGROUND Articular cartilage undergoes an important maturation process from neonate to adult that is reflected by alterations in matrix protein organization and increased heterogeneity of chondrocyte morphology. In the horse, these changes are influenced by exercise during the first five months of postnatal life. Transcriptional profiling was used to evaluate changes in articular chondrocyte ...

Magnetic resonance imaging (MRI) is a non-invasive potential imaging method to diagnose the cartilage disorder. Degeneration of the articular cartilage has been recognized as the main cause of osteoarthritis (OA). Normally OA refers to the end-stage which is already incurable. Therefore, in this study, a noninvasive method is develop to characterize the grayscale of the MRI images for articular...

Current musculoskeletal imaging techniques usually target the macro-morphology of articular cartilage or use histological analysis. These techniques are able to reveal advanced osteoarthritic changes in articular cartilage but fail to give detailed information to distinguish early osteoarthritis from healthy cartilage, and this necessitates high-resolution imaging techniques measuring cells and...

Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, inflict an enormous health care burden on society. Osteoarthritis, a degenerative joint disease with high prevalence among older people, and rheumatoid arthritis, an autoimmune inflammatory disease, both lead to irreversible structural and functional damage to articular cartilage. The aim of this study was to investigate the e...

A tetrapolar method to measure electrical conductivity of cartilage and bone, and to estimate the thickness of articular cartilage attached to bone, was developed. We determined the electrical conductivity of humeral head bovine articular cartilage and subchondral bone from a 1- to 2-year-old steer to be 1.14+/-0.11 S/m (mean+/-sd, n =11) and 0.306+/-0.034 S/m, (mean+/-sd, n =3), respectively. ...

Objective- Postoperative pain management in patients that undergone arthroscopy is one of the most important procedures for their rehabilitation. Analgesic injection intra-articularly can facilitate pain control in such patients. The aim of this study was to evaluate the effects of ketamine on articular cartilage in rat model. Design- Experimental study. Animals- Twenty Wistar Rats Procedure...

INTRODUCTION Signals from the epidermal growth factor receptor (EGFR) have typically been considered to provide catabolic activities in articular cartilage, and accordingly have been suggested to have a causal role in osteoarthritis progression. The aim of this study was to determine in vivo roles for endogenous EGFR signal activation in articular cartilage. METHODS Transgenic mice with condi...

PURPOSE The purpose of this study was to investigate the relation between isolated discoid lateral meniscus (DLM) tears and the presence of articular cartilage lesions. METHODS From January 2010 to January 2012, 252 consecutive patients diagnosed with an isolated DLM tear during an arthroscopic procedure were included in this study. Demographic variables, including gender, age, body mass inde...

Objective(s) Articular cartilage tissue defects cannot be repaired by the proliferation of resident chondrocytes. Autologous chondrocyte transplantation (ACT) is a relatively new therapeutic approach to cover full thickness articular cartilage defects by in vitro grown chondrocytes from the joint of a patient. Therefore, we investigated the redifferentiation capability of human chondrocytes ma...