BACKGROUND Innate immunity is of major importance in vascular repair. The present study evaluated whether systemic and transient depletion of monocytes and macrophages with liposome-encapsulated bisphosphonates inhibits experimental in-stent neointimal formation. METHODS AND RESULTS Rabbits fed on a hypercholesterolemic diet underwent bilateral iliac artery balloon denudation and stent deploy...

369 intravenous adenosine is known to adversely cause facial flushing, headache, palpitations, light headedness, dizziness, blurring of vision and nausea, the local pain or discomfort and local flushing are not described. These adverse events were probably caused by intra-arterial injection of adenosine in the given case. In a clinical trial done by Costa et al [6] , adenosine injection in the ...

regarding the increasing numbers of iv drug addicts, the incidence of infected pseudoaneurysm is increasing. so far, different therapeutic strategies have been tried, but each method has its own drawbacks. therefore, discovering an appropriate therapeutic method is necessary. 65 patients with infected pseudoaneurysm due to drug injection referred to shohada medical center from feb 1994 till oct...

Background: The study aimed to evaluate the interval between first drug use and regular injection and factors associated with transition from first injection into premature regular injection among people who inject drugs (PWIDs).Methods: In a multicenter cross-sectional study, we recruited 400 PWIDs using snowball sampling. Age of first drug use, age of initiation of regular injection, and demo...

we report a case of nicolau syndrome in a 15 months old girl following of an intramuscular injection of penicillin 6.3.3 in her left buttock. this case is unique because she developed compartment syndrome in her left calf far from her injection site. her toe’s tips gangrened in the course of her ailment. we hypothesized that the compartment syndrome might be produced by a probable intra-arteria...

Introduction Livedoid and gangrenous dermatitis is a rare posttherapeutic accident, produced by intravenous, intramuscular or intra-arterial drug injection under an oily or suspension form. In the first stage, artery and branches embolization occurs or there is wall irritation. In the second stage thrombosis or arterial spasms follow and acute ischemia syndrome of segmental skin occurs. The ext...

Dr E J VELLA (Pathology Laboratory, Lakin Road, Warwick CV34 5BJ) and Dr C W EDWARDS (Departme9e of Pathology, East Birmingham Hospital, Birmingham B9 5ST) write: A 31 year old female drug misuser presented with pain in her right leg. She told the casualty doctor that a few hours previously she had crushed a few 10 mg tablets of temazepam, dissolved them in water, and injected the solution intr...

results the mean age was 45.6 ± 13.1 (24 to 74 ) years. twenty-two were normal responders [considered as non-organic causes (37.3% of all patients)], 27 were classified as venous leakage, eight had arterial insufficiency and two were mixed type. maximum psv occurred before the fifth minute in 47 patients (92.2%). eight patients completed all phases of erection in the first 5 minutes. we defined...