After reviewing the epidemiological studies of persons exposed to ionizing radiation, the author concludes that there is no question that radiation exposure in man is asso ciated with an increased incidence of leukemia and that a cause-and-effect relationship must be accepted. Such an association holds in the higher dose range regardless of (a) sex and age, (6) the amount of body exposed (provi...

Renewed interest is being directed toward chemoprevention as a means of reducing cancer mortality. I'o overcome the inherent problems asso ciated with using cancer development as a study end point, there has recently been a great surge of interest in defining the biomarkers asso ciated with specific stages of the carcinogenic process as intermediate end points. We have detailed the evidence sup...

Prostate cancer incidence was prospective!)' studied among 7999 men of Japanese ancestry who were first examined between 1965 and 1968 and then followed through 1986. During this surveillance period, 174 incident cases of prostate cancer were recorded. Prostate cancer was not associated with any measure of socioeconomic status, including amount of education, type of occupation, and type of resi...