An ortho-nitrophenol solution was injected into the intestine which had been removed from an anesthetized mouse by placing a ligature at the duodenum and at the rectum. The intestine was then incubated in Ringer's solution at 37•Ž and the ortho-nitrophenol was found to be reduced to ortho aminophenol. At the same time, it was found that ortho-nitrophenol which was incubated with the intestinal ...

The metal-free reduction of nitro compounds to amines mediated by trichlorosilane was successfully performed for the first time under continuous-flow conditions. Aromatic as well as aliphatic nitro derivatives were converted to the corresponding primary amines in high yields and very short reaction times with no need for purification. The methodology was also extended to the synthesis of two sy...

Single-step reduction of aryl nitro and carbonyl groups to the corresponding synthetically useful alkyl-anilines occurs with excellent yields by treatment with hydrazine and a base in a solvent-free reaction. The method has been applied to a broad range of compounds with different properties. Investigations into the mechanism of the reduction reveal that each group is reduced independently. A m...

The reduction of several aromatic nitro compounds to amines by means the two novel catalytic systems ([IMes]2ReOBr3)/PhSiH3 and ([Py]3ReNOBr2)/PhSiH3 under microwave irradiation is here reported. These were able perform groups with higher TON TOF when compared previously reported based on oxo-rhenium core standard heating, although they showed a lesser broad reaction scope known systems.

A new series of N-{4-(6-Chloro-5-nitro-1-[2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol-2yl-}-phenyl)-3-(substituted-phenyl)-acryl amide derivatives [1-8] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series displayed, remarkable activity in comparison to standard drug(losratan ). Many Schiff bases were prepare...

SYNTHESIS 2006, No. 19, pp 3316–3340xx.xx.2006 Advanced online publication: 06.09.2006 DOI: 10.1055/s-2006-950231; Art ID: C04506SS © Georg Thieme Verlag Stuttgart · New York Abstract: A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to b...

A dye-sensitized metal-organic framework, TMU-5S, was synthesized based on introducing the laser dye Rhodamine B into the porous framework TMU-5. TMU-5S was investigated as a ratiometric fluorescent sensor for the detection of explosive nitro aromatic compounds and showed four times greater selectivity to picric acid than any state-of-the-art luminescent-based sensor. Moreover, it can selective...

substituted schiff bases (hydrazones) 5a-j have been prepared from the starting material 2-chloro pyridine-3-carboxylic acid 1 by a sequence of reactions like reaction with 2-amino-6-nitro benzothiazole (ullamann condensation), thionyl chloride, hydrazine hydrate and different aromatic aldehydes. on cyclocondensation of 5a-j with thioglycolic acid in dry 1,4-dioxane furnished desired compounds ...

Mutagenic activity of nine nitro derivatives of benzanthrone, namely 1-nitro-, 2-nitro-, 3-nitro-, 9-nitro-, 11-nitro-, 1,9-dinitro-, 3,9-dinitro-, 3,11-dinitro- and 3,9,11-trinitrobenzanthrone were tested with Salmonella strains TA98, TA100, YG1021 and YG1024 in both the presence and absence of an S9 mix. Each compound exhibited mutagenic activity with all the strains. Among these nine isomers...