The direct three component modified Mannich reaction via condensation of aldehydes, 2-naphthol or 2,7-naphthalendiol and piperidine to generate Betti bases has been carried out over L-proline (20 mol%) with high efficiency under solvent free conditions at 70 OC. Also, the reaction of aromatic aldehyde and 4-hydroxycoumarin in the presence of L-proline (20 mol%) in the ethanol under reflux condi...

a simple and environmentally benign procedure for the synthesis of 14-aryl-14h-dibenzo[a,j]xanthenes by a one-pot condensation of 2-naphthol with aromatic aldehyde in the presence of [et3nh][hso4] as an acidic ionic liquid catalyst under solvent-free conditions has been developed. the reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused s...

the direct three component modified mannich reaction via condensation of aldehydes, 2-naphthol or 2,7-naphthalendiol and piperidine to generate betti bases has been carried out over l-proline (20 mol%) with high efficiency under solvent free conditions at 70 oc. also, the reaction of aromatic aldehyde and 4-hydroxycoumarin in the presence of l-proline (20 mol%) in the ethanol under reflux condi...

an electroorganic reaction for the synthesis of 7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1h-pyrano[2, 3-d] pyrimidine-6-carbonitrile and ethyl-7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1h-pyrano[2, 3-d] pyrimidine-6-carboxylate derivatives are described, using an electrogenerated base of the anion of malonitrile or ethylcyanoacetate. this one-pot, three-component condensation of an a...

A Schiff base 3 has been synthesized by equimolar reaction (condensation) of sulfonamide i.e. sulfamethoxypyridazine 1 and substituted aromatic aldehyde i.e. 2-Hydroxy-1-Napthalene aldehyde 2. The synthesized Schiff base 3 and its Metal (II) complexes were characterized by its physical, analytical (CHN analysis) and spectral (UV & IR) analysis. The Staphylococcus aureus and Escherichia coli bac...

      A series of N-substituted-2,4-thiazolidinedione derivatives (TZDs) were prepared via N-alkylation of 2,4-TZD at position 3 using substituted benzyl halides. Synthesized N-substituted-2,4-TZD was then substituted at position 5 with substituted aromatic aldehyde according to Knoevenagel condensation method. Structures of the compounds were elucidated using various spectral techniques viz. I...

An aldehyde dehydrogenase (ALDH) with properties identical to those nl the NADP*-dependent, tumor-associated aldehyde dehydrogenase ap pearing during rat hepatocarcinogenesis has been identified in normal rat urinary bladder. Like the tumor-associated aldehyde dehydrogenase, bladder 1\ADP*-ALDH is cytosolic and preferentially oxidizes benzaldchydc-like aromatic aldehydes. Bladder ALDH is also e...

Molybdenum-containing enzymes, aldehyde oxidase and xanthine oxidase, are important in the oxidation of N-heterocyclic xenobiotics. However, the role of these enzymes in the oxidation of drug-derived aldehydes has not been established. The present investigation describes the interaction of eleven structurally related benzaldehydes with guinea pig liver aldehyde oxidase and bovine milk xanthine ...

A simple and environmentally benign procedure for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthenes by a one-pot condensation of 2-naphthol with aromatic aldehyde in the presence of [Et3NH][HSO4] as an acidic ionic liquid catalyst under solvent-free conditions has been developed. The reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused s...