The lunar meteorite Dhofar 1436 is dominated by solar wind type noble gases. Solar argon equilibrated with “parentless” 40Ar commonly known as orphan argon. Ar-Ar isochron analyses determined the trapped 40Ar/36Ar ratio to 2.51 ± 0.04, yielding a corrected plateau age of 4.1 0.1 Ga, consistent Late Heavy Bombardment period. Lunar and radiogenic components are all released at high temperatures (...

Allergic rhinitis (AR) is a common comorbidity of asthma that contributes to asthma severity. Although over 80 % of asthmatics have AR, the condition is frequently underdiagnosed in subjects with asthma. AR itself is also a highly prevalent condition, affecting 10-30 % of adults and up to 40 % of children. AR has been associated with both increased risk of asthma development and asthma severity...

Parent bodies of meteorites have experienced a variety of thermal events caused by early internal metamorphism and impact heating. Among radiometric chronometers, the 39 Ar-40 Ar technique is particularly sensitive to such thermal events. For over two decades the JSC laboratory has acquired 39 Ar-40 Ar data on a wide variety of meteorite types. The purpose here is to summarize some JSC data (an...

Androgens signal through the androgen receptor (AR) to regulate male secondary sexual characteristics, reproductive tract development, prostate function, sperm production, bone and muscle mass as well as body hair growth among other functions. We developed a transgenic mouse model in which endogenous AR expression was replaced by a functionally modified AR transgene. A bacterial artificial chro...

The aim of this study was to review the literature to evaluate the association between allergic rhinitis (AR) and obstructive sleep apnea syndrome (OSAS) in childhood. A PubMed literature search (January 1970 to February 2005) was conducted using the following key words: obstructive sleep apnea, allergic rhinitis, and mouth breathing. The retrieved articles were reviewed and the levels of evide...

The presence of serum autoantibodies in periodontitis (P) patients against β(1)-adrenoceptor (β(1)-AR), using cardiac membranes or a synthetic β(1)-AR peptide corresponding to the second extracellular loop of human β(1)-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HR...

Noninvasive methods to diagnose rejection of renal allografts are unavailable. Mass spectrometry followed by multiple-reaction monitoring provides a unique approach to identify disease-specific urine peptide biomarkers. Here, we performed urine peptidomic analysis of 70 unique samples from 50 renal transplant patients and 20 controls (n = 20), identifying a specific panel of 40 peptides for acu...