Objective: To examine the overlap between autistic traits and other behavioural problems in a general population sample, and explore whether this overlap is of genetic or environmental origin. Method: Youth Self Report (YSR) data were collected in a general population sample of 424 twin pairs at 8 years of age, and their non-twin siblings. In 97 of these families self-report ratings on the Au...

Predictors of recurrence in lone atrial fibrillation have not been clearly identified. Acoustic quantification (AQ) is a promising method in the assessment of left atrial (LA) volumes. The purpose of the present study was to investigate the potential of LA volumes obtained by standard manual tracing and AQ methods in predicting AF-recurrence after restoring the sinus rhythm in patients with lon...

We investigated the safety and efficacy of amodiaquine alone (AQ) and combined with artesunate (AQ + AS) in 308 Rwandan children 6-59 months old with uncomplicated Plasmodium falciparum malaria attending three sentinel sites. The two treatment regimes were well tolerated and no serious adverse events were recorded. After excluding new infections, children treated with AQ + AS had fewer clinical...

OBJECTIVES To determine the efficacy of a novel antimicrobial compound, AQ+, against a genetically heterogeneous collection comprising 213 Staphylococcus aureus isolates from global sources. AQ+ is an aqueous preparation containing 0.5% 8-hydroxyquinoline. METHODS MICs were found for all the isolates tested using the BSAC microdilution method. Time-kill studies were performed according to NCC...

In the current study, we fit confirmatory bi-factor models to the items of the Autism Spectrum Quotient (AQ) and Autism Spectrum Quotient Short Form (AQ-S) in order to assess the extents to which the items of each reflect general versus specific factors. The models were fit in a combined sample of individuals with and without a clinical diagnosis of autism spectrum disorders. Results indicated ...

the present research has been conducted to investigate the soda and soda-anthraquiuone pulping from whole kenaf (v36). in this respect, anatomical characteristics of kenaf bast and core fibers as well as the soda and soda-aq pulp properties produced at four sodium hydroxide concentrations, namely 25, 30, 35 and 40 (g/lit), have been evaluated. the pulping results indicated that pulp yield and k...

Amodiaquine (AQ) metabolism to N-desethylamodiaquine (DEAQ) is the principal route of disposition in humans. Using human liver microsomes and two sets of recombinant human cytochrome P450 isoforms (from lymphoblastoids and yeast) we performed studies to identify the CYP isoform(s) involved in the metabolism of AQ. CYP2C8 was the main hepatic isoform that cleared AQ and catalyzed the formation o...

BACKGROUND The use of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment in pregnancy (IPTp) is threatened by the spread of resistance to SP. Therefore, we studied the efficacy, safety, and tolerance of amodiaquine (AQ) or the combination of AQ and SP (SPAQ) as possible alternative treatments. METHODS The study was performed in Ghana from June 2004 through February 2007. Wom...