Macrophages are cells of the immune system that protect organisms against invading pathogens by fulfilling critical roles in innate and adaptive immunity and inflammation. They originate from circulating monocytes and show a high degree of heterogeneity, which reflects the specialization of function given by different anatomical locations. Differentiation of monocytes towards a macrophage pheno...

Abstract Objective Definitive chemoradiotherapy (dCRT) is one of the standard treatments for esophageal squamous cell carcinoma (ESCC), but local recurrence main cause treatment failure. The changes in apoptosis and autophagy recurrent tumors patients with ESCC following dCRT have been poorly estimated. Thus, this study aimed to investigate expressions key regulators matched paired samples prim...

Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV) are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature ...

BACKGROUND Arsenic Trioxide (ATO) is effective in about 20% of patients with myelodysplasia (MDS); its mechanisms of action have already been evaluated in vitro, but the in vivo activity is still not fully understood. Since ATO induces apoptosis in in vitro models, we compared the expression of 93 apoptotic genes in patients' bone marrow before and after ATO treatment. For this analysis, we sel...

ABSTRACT The objective of the present study was to evaluate effect lipopolysaccharide (LPS) administration on activation and apoptosis primordial follicles. There no difference in total number follicles as well different types Furthermore, LPS challenge didn’t modulate expression genes related with ovarian reserve (HAM), oocyte survival (Survivin), rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), f...

Natural products have been studied to provide alternative treatments against human diseases as they various medicinal properties. One of these natural is substances in the class flavonoids. These bioactive molecules antioxidant, anti-inflammatory and antitumor activities. The number studies focusing on increasing discover new therapeutic agents such cancer. We aimed determine in-vitro anticance...

Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of water extract senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231).Methods: The MTT assay was to assess proliferation. expression apoptosis-related genes assessed by quantitative real-time PCR.Results: ASF treatme...

background glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches are facing progressive failure because of the resista...