introduction: although the initial hypothesis for the action of doxepin was based on the inhibition of the reuptake of neurotransmitters, it has been suggested that it may also involve other mechanisms. therefore, this study aims to investigate the effect of doxepin on spatial memory, tumor necrosis factor alpha (tnf-α) level, expression of pro-apoptotic (bad and bax) and anti-apoptotic (bcl-2)...

background: linoleic acid (la) is a polyunsaturated fatty acid present in high concentrations in follicular fluid, when added to maturation culture media, it affects oocyte competence.objective: in the present study, we investigated effect of linoleic acid supplementation on in vitro maturation, embryo development and apoptotic related gene expression in ovinematerials and methods: the experime...

Nobiletin is considered a phyto-flavonoid extracted from citrus peel and shown to several pharmacological roles such as anti-inflammatory, anti-tumor neuroprotective properties. In this study, we investigate the role of nobiletin combined docetaxel enhances apoptosis in colorectal cancer cell lines. Our results confirmed enhanced docetaxel-induced reactive oxygen species generation human carcin...

Background: DNA molecule of the eukaryotic cells is found in the form of a nucleoprotein complex named chromatin. Two epigenetic modifications are critical for transcriptional control of genes, including acetylation and DNA methylation. Hypermethylation of tumor suppressor genes is catalyzed by various DNA methyltransferase enzymes (DNMTs), including DNMT1, DNMT2, and DNMT3. The most well chara...

Background: In reproductive biology, testicular organoids can be used to treat infertility and study development spermatogonial stem cells (SSCs) differentiation. Generating organoid from primary is challenging. this study, were created using human evaluated the apoptotic gene expression hormone secretion profiles of organoids. Materials Methods: Primary isolated 2-step enzymatic digestion thre...

ophiocoma erinaceus muller &troschel; (ophiocomidae) is part of the extensive group of echinoderm that contains bioactive metabolites. as, the anti cancer potential of brittle star saponin has not been reported against cervical cancer, the present study was conducted to evaluate the anticancer effect of extracted crude saponin. saponin extraction was conducted using conventional method such as ...

This study aims to investigate the effects of kimchi made with organic ingredients and lactic acid bacteria (LAB) as starters (Leuconostoc mesenteroides + Lactiplantibacillus plantarum) on HT-29 human colon carcinoma cells. Four types (standard (SK), commercial (CK), anticancer (AK), (OAK)) were evaluated. The results show that, among different studied, OAK presents high DPPH free-radical scave...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...