نتایج جستجو برای: apoptosis repressor withcaspase recruitment dom
تعداد نتایج: 233104 فیلتر نتایج به سال:
The members of the Myc/Max/Mad network function as transcriptional regulators. Substantial evidence has been accumulated over the last years that support the model that Myc/Max/Mad proteins affect different aspects of cell behavior, including proliferation, differentiation, and apoptosis, by modulating distinct target genes. The unbalanced expression of these genes, e.g. in response to deregula...
Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half of cancers have p53 loss-of-function mutations. Here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (ARC), a protein induced in multiple cancer cells. The direct binding in the nucleus of ARC to the p53 tetramerization domain inhibit...
The effects of dissolved organic matter (DOM), derived from compost, on the sorption of simazine by soils were studied using a batch equilibrium technique. Six soils with different organic carbon contents were investigated in this study. Simazine sorption isotherms on soils were described by the linear equation, and the distribution coefficients without DOM (Kd) or with DOM (Kd*) were obtained....
Chemotherapy for acute myeloid leukemia (AML) principally induces intrinsic apoptosis in circulating leukemic blasts. Unfortunately, standard therapy is relatively ineffective in eliminating AML stem/progenitor cells that drive leukemogenesis. The inhibitors of apoptosis (IAP) protein family are critical regulators of cell survival. IAP proteins, in particular cIAP1 and cIAP2, have drawn great ...
Duchenne muscular dystrophy is an X-linked recessive disorder, primarily characterized by progressive muscle weakness and wasting. The disease results from the absence of dystrophin, however the precise molecular mechanisms leading to muscle pathology are poorly understood. Dystrophic muscles undergo increased oxidative stress and altered calcium homeostasis, which may contribute to myofiber lo...
BACKGROUND Pulmonary hypertension (PH) is a lethal syndrome associated with the pathogenic remodeling of the pulmonary vasculature and the emergence of apoptosis-resistant cells. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of multiple forms of cell death known to be abundantly expressed in striated muscle. We show for the first time that ARC is expressed in arteria...
In this study, we show that CK2 (casein kinase II, CKII) participates in apoptotic responses following ionizing radiation (IR). Using HeLa human cervical carcinoma cells, we find that transfection of small interfering RNA against the CK2 alpha and/or alpha' catalytic subunits results in enhanced apoptosis following IR damage as measured by flow cytometry techniques, compared with a control smal...
We present a technique that classifies users’ age group, i.e., child or adult, from touch coordinates captured on touch-screen devices. Our technique delivered 86.5% accuracy (user-independent) on a dataset of 119 participants (89 children ages 3 to 6) when classifying each touch event one at a time and up to 99% accuracy when using a window of 7+ consecutive touches. Our results establish that...
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