This study aimed to investigate whether Opuntia spp-extracts protect against diclofenac (DF)-induced hepatotoxicity. Rats were pretreated with extracts, betanin (Bet) and N-acetylcysteine (NAC) followed by a single challenge of diclofenac. Liver tissue was collected for biochemical histological analysis. Primary rat hepatocytes treated (400 µmol/L) without pretreatment extract. Apoptosis measur...

Introduction: In the present study, we assessed the effects of β-carotene on Titanium oxide Nanoparticle (TNP) induced mouse Spermatozoon Stem Cells (SSCs) apoptosis, at molecular level.  Methods: After isolation from cryptorchid mouse testis and characterization, spermatogonial stem cells were divided into four groups. In the control group, spermatogonial cells were cultured in &alp...

conclusions in general, it seems that three-month exercise training was effective in reducing cardiac mitochondrial pro-apoptotic protein. however, considering the results of the bcl2 gene expression, more researches are needed to identify effects of exercise trainings on indices of myocardial apoptosis. objectives the aim of this study was to assess the effect of exercise training on bcl-2 and...

Mitochondrial biogenesis is a cell response to external stimuli which generally believed suppress apoptosis. However, during the process of apoptosis, whether mitochondrial occurs in early stage apoptotic cells remains unclear. To address this question, we constructed COX8-EGFP-ACTIN-mCherry HeLa with recombinant fluorescent proteins respectively tagged on nucleus and mitochondria, monitored ch...

Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of TP53 mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and TP53 mutations in no...

Malignant glioma by surgery is difficult to completely remove, the recurrence rate high, survival period short and prognosis poor, which poses a great threat human health. This article mainly studies related process that curcumin induces cell apoptosis promoting reactive oxygen species production. In experiment, cells were processed Uppsala 87 malignant of cultured in vitro. 3-(4, 5-dimethylthi...

Abstract Background Dysregulation of the balance between proliferation and apoptosis is basis for human hepatocarcinogenesis. In many malignant tumors, such as hepatocellular carcinoma (HCC), there a correlation apoptotic dysregulation poor prognosis. However, prognostic values apoptosis-related genes (ARGs) in HCC have not been elucidated. Methods To screen differentially expressed ARGs, expre...

Lung cancer is a malignancy characterized by high morbidity and mortality, with lung adenocarcinoma being the most prevalent subtype. Our preliminary studies have demonstrated that Juan-Liu-San-Jie (JLSJ) prescription, Traditional Chinese Medicine possesses anti-lung properties. However, molecular mechanism underlying therapeutic effects of JLSJ prescription for remains incompletely elucidated....