The major protein of high density lipoprotein (HDL), apolipoprotein (apo) A-I, is the major activator of the plasma enzyme lecithin:cholesterol acyltransferase (LCAT). A consensus amino acid sequence has been defined for the eight, 22-residue long, tandem amphipathic helical repeats located in the carboxy-terminal region of apo A-I. A series of 22 and 44mer synthetic peptide analogues of the co...

Abstract Apolipoprotein A-I Milano (Apo ) is a natural mutant of Apolipoprotein. It currently the only protein that can clear arterial wall thrombus deposits and promptly alleviate acute myocardial ischemia. Apo considered as most promising therapeutic for treating atherosclerotic diseases without obvious toxic or side effects. However, current biopharmaceutical platforms are not efficient deve...

We performed temporal and thermal stability studies on SP3-07, a liquid-stabilized reference material for apolipoprotein (apo) B, selected during the previous phase of the International Federation of Clinical Chemistry project on standardization of apolipoprotein measurements. Results indicate that SP3-07 stored at -70 degrees C has the long-term stability required for a reference material. We ...

OBJECTIVE To assess if the apolipoprotein (Apo) B/Apo A-I ratio in Saudi patients with type 2 diabetes mellitus (T2DM) is associated with metabolic syndrome (MetS). METHODS This cross-sectional study was conducted on 250 patients with T2DM, above 40 years of age, at King Abdulaziz University Hospital Diabetes Center in Riyadh, Saudi Arabia, between January and December 2006. Metabolic syndrom...

OBJECTIVE This study was performed to investigate whether a high ratio of apolipoprotein B to apolipoprotein A1 (apo B/apo A1 ratio) is significantly associated with the risk of developing non-traumatic osteonecrosis of the femoral head (ON). METHODS Fifty consecutive non-traumatic ON cases were compared with 50 age and sex matched controls, using both univariate and stepwise discriminant ana...

Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot analysis of 13 hybrids localized the gene to human chromosome 11. Confirmation...

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abstract   background: recently, small dense low density lipoprotein (sdldl) has been highlighted as a new risk factor for the coronary artery disease (cad).small dense ldls are believed to be atherogenic since these particles are taken up more easily by arterial wall. they are readily oxidized and have reduced affinity for low density lipoprotein (ldl) receptor and increased affinity for arter...

We have reported previously on two truncations of apolipoprotein B (apo B-40 and apo B-89) in a kindred with hypobetalipoproteinemia. Premature stop codons were found to be responsible for both apo B-40 and apo B-89, but the physiologic mechanisms accounting for the reduced plasma concentrations of these proteins have not been determined in vivo. This study investigates the metabolism of apo B-...