Well-formed hidradenitis suppurative is extremely resistant to conservative manageniek and at the same time can become incapacitating to the patient. Radical surgical excision ofthe diseased area and resurfacing can bring about rapid and dramatic improvement in such patients. Two severe cases of hfdradenitis of the perineal region are presented. Apocrinitis or hidradenitis is an inflammatory co...

Ever since Sir James Paget first described the disease of the nipple named after him and remarked that he had seen a lesion clinically resembling it on the glans penis, followed by cancer, reputed cases of extramammary Paget’s disease have been sporadically reported and their nature discussed. The debate has been ancillary to the related question of the nature of Paget’s disease, which is still...

Recently, it has been demonstrated how apocrine glands, as well as several cutaneous apocrine tumors, do not express calretinin. In the current report, we studied calretinin immunoexpression in 33 cases of cutaneous metastases of ductal breast carcinoma, as well as in seven primary cutaneous apocrine tumors. We also tested the hormonal status of all cases for estrogen receptors (ER), progestero...

The atypical cutaneous tumor of a 9-year-old mixed breed female dog was examined. The tumor was well-demarcated and histologically composed of a trichoblastic area, tricholemmal area and apocrine glandular area. Neoplastic cells in trichoblastic area and tricholemmal area had PAS-positive granules in the cytoplasm and were positive for pan-cytokeratin, cytokeratin 5/6, 14 and 19 and p63. Neopla...

Walter Gebhart, MD, Department of Dermatology II, University of Vienna, Vienna (Austria) The past decade’s explosive progress in dermatological research is not only tightly linked to ever improving biochemical, immunological or micromorphological methodology, but also grounded in partnership with rapid and reliable distribution of data at an international level. The paper ‘Idiopathic acquired g...

BACKGROUND The aim of the present study was to evaluate, by immunohistochemical staining, metallothionein expression in normal, benign and malignant canine apocrine gland tissues and to correlate the protein expression with the histological grade of malignancy. MATERIALS AND METHODS MT immunostaining was evaluated in 25 formalin-fixed and paraffin-embedded canine apocrine glands (2 normal and...

The histology, histochemistry, and ultrastructure of the adhesive breeding glands of male Gastrophryne carolinensis are described. Adhesive glands are mutlicellular exocrine glands in the dermis of the sternum and forearm that cause the male to adhere to the female during amplexus. The epithelial cells have distinct plasma membranes, and the product consists of electron-dense secretory granules...

Canine apocrine gland carcinoma is a locally aggressive neoplasm that can occasionally lead to metastatic spread, thus mimicking the behavior of their human counterpart. In this paper we describe the successful treatment of a cervical metastatic spread of this neoplasia by using mitoxantrone selectively driven within the tumor cells by trains of biphasic pulses. The dog experienced tumor reduct...

Fox-Fordyce disease (FFD) is a rare inflammatory disorder that affects the apocrine sweat glands. Clinically, lesions are equidistant, smooth, uniform, firm, folliculocentric papules, which can range in color from flesh-colored to red-brown to slightly yellow. Whereas the axillae are most commonly involved, FFD also can involve the anogenital and periareolar areas, lips, umbilicus, sternum, per...