Apolipoprotein (apo) E phenotype is an important genetic determinant of plasma low-density lipoprotein (LDL) cholesterol and apo B levels. We have determined apo E phenotype by isoelectric focusing and plasma lipid, lipoprotein cholesterol, apo A-I, apo B, and lipoprotein(a) levels, as well as LDL particle size, in 2258 men and women participating in the Framingham Offspring Study. Apo E phenot...

To study the effect of insulin on lipoprotein synthesis and secretion by the liver, apoprotein and lipid levels were measured in primary rat liver cell cultures grown on fibronectin-coated dishes. Triglycerides, phospholipids, apoprotein (apo) B, apo-E, and apo-C-III3 all accumulated in culture media linearly for periods up to 20 h. During incubations, cellular triglyceride contents increased s...

OBJECTIVE To determine whether apo E phenotype influences changes in lipid profiles induced by growth hormone replacement in growth hormone (GH)-deficient adults. DESIGNS Patients were treated for 6 months with recombinant human GH (hGH), given in a dose of 0.125 U/kg per week for 4 weeks followed by 0.25 U/kg per week thereafter. The effects on serum lipids and the influence of apo E phenoty...

Apolipoprotein E (Apo E) is a polymorphic secretory glycoprotein expressed by a wide variety of tissues in mammals, particularly the liver and the brain (Mahley, 1988). Apo E recently attracted considerable attention when it was found that one of its alleles, apo E4, was associated with an increased risk for Alzheimer's disease (Strittmatter et al. 1993 a). This protein has been well studied wi...

Although familial hypercholesterolemia (FH) has been well characterized in terms of the etiology of the major lipoprotein abnormality, that of low density lipoproteins (LDL), less information is available on changes in other lipoproteins which could influence the atherogenic process in this disorder. The present study has focused on such potential abnormalities by studying in detail the lipopro...

Hyperlipidemia associated with hypothyroidism is well documented in man and several animal species. The effect of hypothyroidism on apolipoprotein metabolism in the absence of complicating factors such as high cholesterol or fat content in the diet is virtually unknown. Hypothyroidism was therefore induced in male Sprague-Dawley rats by radiothyroidectomy (RTx-treated) or treatment with propylt...

The kinetics of apolipoprotein (apo) B-100 in particles containing apo E (B,E particles) or lacking apo E (B particles) were studied in Watanabe heritable hyperlipidemic (WHHL) rabbits deficient in low density lipoprotein (LDL) receptors, and compared with those of normal rabbits after injection of radioiodinated very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and...

background: this study investigated blackberry (persian mulberry) effects on apo a-i, apo b, high-sensitivity-c-reactive protein (hs-crp), and systolic blood pressure (sbp) and diastolic blood pressure (dbp) in dyslipidemic patients. materials and methods: in this 8-week randomized clinical trial, 72 dyslipidemic patients were randomly divided into two groups: intervention (300 ml/day blackberr...

abstract   background: obesity is directly related to dyslipidemia which contributes significantly to the risk of coronary heart disease, a major cardiovascular disease and a serious health problem. the aim of this study was to compare the effects of low calorie diet and those of lovastatin on serum lipoproteins, apo b, homocysteine, and total antioxidant capacity (tac) in hyperlipidemic obese ...

In a group of 303 healthy Caucasian adults of both sexes we studied the influence of the apolipoprotein E (apo E) polymorphism on plasma levels of Lipoprotein(a) (Lp(a). The APOE*2 allele was found to decrease the mean plasma Lp(a) level by 24.8%, whereas the APOE*4 allele increased the mean Lp(a) level by 25.7%. These effects were parallel to the effect of apo E polymorphism on plasma choleste...