Ste, bark of pongamia pinnata, a medicinal tree of importance in Ayurveda has been subjected to various pharmacological studies using the aqueous extract in different dose levels. The aqueous extract of bark exhibited significant CNS sedative and antipyretic effects in experimental animals. But there was no effect on cardiovascular system, through it showed antispasmodic effects on smooth muscl...

BACKGROUND The fruit of Rosa moschata has traditionally been used for the treatment of abdominal spasm and diarrhoea. Therefore, the aim of this study was to investigate mechanism(s) responsible for its medicinal use in gut spasm and diarrhea. METHODS Hydro-methanolic extract of Rosa moschata (Rm.Cr) was studied in isolated rabbit's jejunal preparations for possible antispasmodic activity. Ba...

I. The Antispasmodic Action of Basic Nitriles. A. M. Lands, Estelle Ananenko, Gwendolyn Jones, James 0. Hoppe and T. J. Becker 1 II. The Effect of Diethylaminoethyl Ester of 1.Phenyl.Cyclopentane-1-Car.. boxylic Acid Hydrochloride, “Parpanit,” on Decerebrate Rigidity, Spinal Reflexes and Skeletal Muscle. Charles M. Gruber, Charles P. Kraatz, Charles M. Gruber, Jr., and Joan E. Copeland 11 III. ...

The relative stereochemistry of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid, a diterpenoid with antispasmodic, hypotensive and antibacterial activities isolated from Salvia cinnabarina, was determined by an X-ray diffraction analysis of a single crystal of a suitable crystalline derivative.

OBJECTIVE Radial artery pedicle tissue cooling during harvesting is one of the major causes of vasospasm. We aimed to compare the effects of the pedicle rewarming method, normothermic organ bath, and one of the most preferred topical antispasmodic agents, verapamil-nitroglycerin solution alone or in combination on the blood flow of radial artery. METHODS Consecutively randomized patients (n=8...

Dracocephalum kotschyi Boiss. is a traditional medicine with antispasmodic activities. The objective of this research was to study antispasmodic activities of hydroalcoholic extract of D. kotschyi on rat isolated uterus contractions for comparison with isolated ileum. Hydroalcoholic extract was obtained from aerial part of D. kotschyi using percolation method. A portion of rat ileum or uterus w...

OBJECTIVE Radial arteries are increasingly used as conduits for coronary artery bypass grafts, but perioperative graft vasospasm remains a concern. In vitro testing has demonstrated the efficacy of phenoxybenzamine and verapamil/nitroglycerin as topical antispasmodic agents, but their duration of action in vivo is unknown. Using an in vivo mouse model, we measured their duration of action in fu...

BACKGROUND In Iranian folk medicine, several plants are used for treatment of gastrointestinal disorders, such as diarrhea and spasm. One of these herbal medications are the essential oil yielded from seeds of Ferula assa-foetida L. and an oleo-gum-resin known as asafetida, which is exudated from its root. F. assa-foetida grows wildly in south and central mountains of Iran. AIM In this study,...