OBJECTIVE The present study was carried out to determine the antinociceptive, anti-inflammatory and antipyretic activities of the aqueous extract of Bauhinia purpurea leaves using animal models. MATERIALS AND METHODS The air-dried, powdered leaves (approximately 20 g) were soaked in distilled water (1:20; w/v) at room temperature for 72 h and the supernatant obtained was freeze-dried. The cru...

Fever is a complex physiologic response triggered by infectious or aseptic stimuli. Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain. These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus. Although fever benefits the nonspecific immune response to invading microorganis...

BACKGROUND AND OBJECTIVE antipyretic therapy for patients with sepsis has long been debated. The present study aimed to explore the beneficial effect of antipyretic therapy for ICU patients with sepsis. DESIGN systematic review and trial sequential analysis of randomized controlled trials. DATABASE Pubmed, Scopus, EBSCO and EMBASE were searched from inception to August 5, 2014. METHODS Mo...

BACKGROUND The present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects. Therefore, new effective agents are the most wanted. The present study investigates the anti-nociceptive, anti-inflammatory and antipyretic activities of crude methanol extract of Hypericum oblongifolium. METHODS In vivo acetic acid indu...

BACKGROUND Pyrexia, algesia and inflammation are associated with several pathological conditions. Synthetic drugs available for the treatment of these conditions cause multiple unwanted effects. Several studies are ongoing worldwide to find natural healing agents with better safety profile. The current study was thus aimed at evaluating antipyretic, analgesic and anti-inflammatory activities of...

Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial Title: [ISRCTN11886401]

Our previous study suggested that the production of superantigens and heat-shock protein 60 by small intestinal bacteria might play a role in Kawasaki disease (KD). We demonstrated that they were all resistant to commonly used antibiotics, except for sulfamethoxazole trimethoprim (SMX-TMP). We used SMX-TMP for 7 cases of KD that were unresponsive to intravenous immunoglobulin (IVIG) and studied...

To determine whether the prevention of fever affects the survival of an animal infected with pathogenic bacteria, lizards (Dipsosaurus dorsalis) were infected with live Aeromonas hydrophila and received varying doses of sodium salicylate, an antipyretic drug. Twelve lizards received identical injections of bacteria along with a nontoxic dose of sodium salicylate; five animals increased their me...

Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial Title: [ISRCTN11886401]