Aim. The aim of this study was evaluate the relationship between preeclampsia and antiphospholipid antibodies. Methods. A total of 116 pregnant women between 20th and 40th weeks of gestation admitted to our department were investigated. 63 of them were allocated our preeclampsia group and 53 of them were allocated our control group. Lupus anticoagulant, anticardiolipin antibodies (IG G ve M) an...

We report here, we believe for the first time, the primary antiphospholipid syndrome, presenting with fever, meningismus and skin rash. Serology was positive for antiphospholipid antibodies but negative for antinuclear factor. Such presentations, once meningitis has been excluded, should be screened for antiphospholipid antibodies. If serology proves to be positive, anticoagulation for life sho...

It is nowwell knownthat symptomssuch as arterial and venous thrombosis, recurrent fetal loss, central nervous system involvement and thrombocytopenia in patients with systemic lupus erythematosus (SLE) are associated with the presence of antiphospholipid antibodies. In addition, antiphospholipid antibodies can be found in patients with no other apparent autoimmune diseases and maycause cerebral...

We report on two patients who have high titres of antiphospholipid antibodies, both of whom had acute audiovestibular failure. One of the patients had systemic lupus erythematosus. The other patient had primary antiphospholipid syndrome: audiovestibular symptoms have not been reported in this condition. The occurrence of acute audiovestibular failure in the primary antiphospholipid syndrome rai...

References 1. Mitsias P, Levine SR. Large cerebral vessel occlusive disease in systemic lupus erythematosus. Neurology. In press. 2. Dungan DD, Jay MS. Stroke in an early adolescent with systemic lupus erythematosus and coexistent antiphospholipid antibodies. Pediatrics. 1992;90:96-99. 3. Tsokos GC, Tsokos M, le Riche NGH, Klippel JH. A clinical and pathological study of cerebrovascular disease...

The antiphospholipid syndrome was initially described in 1986. To reassess the validity of antiphospholipid antibodies in systemic lupus erythematosus (SLE), 95 patients with SLE were studied. Their antiphospholipid antibody profile was analysed and correlated with clinical findings such as thrombosis, abortions, or thrombocytopenia. A low prevalence of these antibodies was found (13 patients; ...

BACKGROUND Although thrombosis is considered the cardinal feature of the antiphospholipid syndrome, chronic vascular lesions are common, particularly in patients with life-threatening complications. In patients who require transplantation, vascular lesions often recur. The molecular pathways involved in the vasculopathy of the antiphospholipid syndrome are unknown, and adequate therapies are la...