abstract introduction: medicinal plants belong to lamiaceae family are potential sources of new drugs to improve the treatment of diseases which its treatment is linked to anti-oxidative agents. in this paper, antioxidant potentials of some lamiaceae species have been evaluated by two methods. methods: phosphomolybdate assay for total antioxidant capacity and ferric reducing antioxidant potenti...

A series of synthesized new 8-[5-aryl-4-octyl-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl]-octanoic acid ethyl esters 1 were evaluated in vitro for their antibacterial and antifungal activity against different organisms. The compounds were tested for their antioxidant activity and their reducing power ability. The structure-activity relationship of the compounds was described.

The lipophilicity of persilben, an important parameter influencing the penetration of the compound through biological membranes, was determined experimentally by dynamic method and was theoretically calculated according to the fragmentation methods introduced by Crippen, Broto and Viswanadhan. The higher value of partition coefficient (log P = 3.89) obtained for persilben than that for resverat...

Disubstituted [1,3,4]-oxadaiazoles (6a-b), Mannich bases (7a-f) and S-alkylated derivatives (8a-f) have been synthesized from 4-(methylsulfonyl/sulfinyl)phenylaceticacid (3a-b) through a multi-step reaction sequence starting from (4-methylthio)phenylacetonitrile (1). The structures of new compounds were established on the basis of their elemental analysis, IR, H NMR, C NMR and mass spectral dat...

Nowadays it is very desirable to investigate and discover new antibacterial and antioxidant agents from natural products and medicinal plants. The current study was conducted to examine the antimicrobial and antioxidant properties of an endemic plant named Caspian saffron, Crocus caspius. After collecting C. caspius and drying them in the shade, ethanol, methanol and hydroalcohol extracts were ...

Multitarget compounds are increasingly being pursued for the effective treatment of complex diseases. Herein, we describe the design and synthesis of a novel class of shogaol-huprine hybrids, purported to hit several key targets involved in Alzheimer's disease. The hybrids have been tested in vitro for their inhibitory activity against human acetylcholinesterase and butyrylcholinesterase and an...

Objective: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. Materials and Methods: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In ...

numerous studies have been focused on natural anticarcinogenic agents. many antioxidants have been identified as anticarcinogens. antimutagens have also been proposed as cancer chemopreventive agents. the use of natural products as anticancer has a long history that began with traditional medicine. the aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...