Leishmania tarentolae promastigotes were selected step by step for resistance to sodium stibogluconate (Pentostam). Mutants resistant to antimony-containing drugs and cross-resistant to arsenite were therefore obtained. Amplification of one common locus was observed in several independent sodium stibogluconate-resistant mutants, and the locus amplified was novel. The copy number of the amplifie...

Part of the northern Palatinate region in Germany is characterized by elevated levels of arsenic and antimony in the soil due to the presence of ore sources and former mining activities. In a biomonitoring study, 218 residents were investigated for a putative increased intake of these elements. Seventy-six nonexposed subjects in a rural region in south lower Saxony were chosen as the reference ...

A few months ago we refused to publish in this journal an advertisement of an antimony preparation which was said to be a specific remedy for malaria in all forms. This preparation appeared to be an ordinary pentavalent one. In our present number we publish an article by P. C. Sen Gupta on malaria complicating kala-azar, in which it is recorded that malaria may occur during or immediately after...

The multilayer antimony-doped tin dioxide coating was obtained by cathodic deposition of multilayer metal-hydroxide coating with near 100-nm thickness layers on the alloy underlayer accompanied by the anodic oxidation of this coating. The potential regions of deposition of tin, antimony, tin-antimony alloy, and mixture of this metals and their hydroxides in the pyrophosphate-tartrate electrolyt...

A method for rapid and accurate determination of trace quantities of SbIII was developed based on its inhibitory effect on the decolorizing reaction of methyl orange in the presence of bromate and bromide ions in acidic media. Decolorization of methyl orange by the reaction products was used to monitor the reaction spectrophotometrically at 525 nm. The method allows determination of antimony in...

The single crystals of the new isostructural compounds Sb3O4F and Y0.5Sb2.5O4F and the two previously known compounds M-SbOF and α-Sb3O2F5 were successfully grown by a hydrothermal technique at 230 °C. The new compound Sb3O4F crystallizes in the monoclinic space group P21/c; a = 5.6107(5) Å, b = 4.6847(5) Å, c = 20.2256(18) Å, β = 94.145(8)°, z = 4. The replacing part of Sb with Y means a sligh...

17 Antimony-based drugs are still the mainstay of chemotherapy against Leishmania infections in 18 many endemic countries. Efficacy of antimonials has been compromised by increasing numbers of 19 resistant infections, the basis of which is not fully understood and likely involves multiple factors. 20 By using a functional cloning strategy he have recently identified a novel antimony resistance ...

Introduction.?The senior writer, Burke (1943), made an appeal for an efficient successor to neostibosan (Bayer), this, preferably, to be a British product. What seems to be an almost perfect answer to that appeal?and indeed a British product?is the preparation stibatin (Glaxo Laboratories), or sodium antimony gluconate (antimony v-hexonate), a crystal-clear sterile solution containing 20 mg. of...

This work report on the structural and electrical characteristics of zinc oxide single crystal samples doped with antimony. Doping was carried out by antimony thermal diffusion at 1000 °C for periods of one and two hours under nitrogen environment from a solid source formed by antimony oxide. X-ray diffraction was used to determine the crystalline phases in samples and the structural change owi...

A model is presented that describes the pumping characteristics of St707 getter material, the evaporation rate of antimony, and the resulting partial pressure of Sb within a vacuum chamber. The results show that within the 250-450◦C range, the partial pressure of antimony ranges from 10−7 Pa to 10−2 Pa. In a limiting case where the getter efficiency is tuned to 10, 000 L/s, partial pressures ar...