Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes wher...

The outbreak of coronavirus disease 2019 (COVID-19) wreaked havoc all across the world, claiming numerous casualties. Managing pandemic has resulted in production an unprecedented volume biomedical waste (BMW), form used personal protective equipment (PPE), diagnostic items, etc. It is a matter utmost urgency that this BMW treated, using newer and environmentally sustainable methods as compared...

We propose antimicrobial photodynamic therapy (aPDT) as an alternative strategy to reduce the use of antibiotics in shrimp larviculture systems. The growth of a multiple antibiotic resistant Vibrio harveyi strain was effectively controlled by treating the cells with Rose Bengal and photosensitizing for 30 min using a halogen lamp. This resulted in the death of >50% of the cells within the first...

The main goal in endodontic treatment is to eradicate or at least reduce intraradicular microbial population to levels that are more compatible with periapical lesions healing process. Since endodontic infections are polymicrobial in nature, intraradicular survival of endodontic microbiota and their pathogenic properties are influenced by a combination of their virulence factors. The purpose of...

Chitosan (CH) is a biopolymer that exhibits a number of interesting properties such as anti-inflammatory and antibacterial activity and is also a promising platform for the incorporation of photosensitizing agents. This study aimed to evaluate the efficacy of antimicrobial activity of chitosan hydrogel formulation alone and in combination with the methylene blue (MB) associated with antimicrobi...

Introduction: Deep periodontal pockets pose a great challenge for nonsurgical periodontal treatment. Scaling and root planing (SRP) alone may not suffice in cases where surgical therapy cannot be undertaken. Various recent studies have suggested the use of antimicrobial Photodynamic Therapy (aPDT) for the management of periodontal infections. The aim of this study was to evaluate the effects of...

OBJECTIVE Recent review articles have shown that open debridement is more effective in the treatment of peri-implantitis than closed therapy. However, surgery may result in marginal recession and compromise esthetics. The purpose of this study was to assess the efficacy of nonsurgical antimicrobial photodynamic therapy (aPDT) in moderate vs severe defects. METHOD AND MATERIALS The study encom...

The persistence of microorganisms in the root canal system is one leading causes treatment failure. Root anatomy complex, and it often a challenge to obtain optimal disinfection. Biofilms putative pathogens hidden inside dentin tubules other ramifications may limit current disinfection protocols. search for additional has been intensely carried out over last twenty years. Antimicrobial photodyn...

BACKGROUND Oral care is important for oral and systemic health, especially for elderly institutionalized individuals and compromised patients. However, conventional mechanical plaque control is often difficult for these patients because of the pain or the risk of aspiration. Although antimicrobial photodynamic therapy (aPDT), which is considered an alternative or adjunct to mechanical approache...

Background: Despite intensive research, the ideal protocol applied to maximize overall benefits of antimicrobial photodynamic therapy (aPDT) remains unexplored. Evidence exists that following aPDT, diffused light beyond photosensitizer can exert a secondary therapeutic effect known as photobiomodulation (PBM), which stimulates healing surrounding tissues. Therefore, aim this study was examine a...