High-resolution two-dimensional (2D) (1)H-(15)N heteronuclear correlation (HETCOR) spectroscopy has been used to characterize the structure and dynamics of (15)N-backbone labeled antimicrobial piscidin 1 (p1) oriented in "native-like" hydrated lipid bilayers. Piscidin belongs to a family of amphipatic cationic antimicrobial peptides, which are membrane-active and have broad spectrum antimicrobi...

AIMS To investigate the appropriateness of the extended Lambert-Pearson model (ELPM) to model the effect of pH (as hydrogen and hydroxyl ions) over the whole biokinetic pH range in comparison with other available models. METHODS AND RESULTS Data for the effect of pH on microbial growth were obtained from the literature or in-house. Data were examined using several models for pH. Models were c...

Antimicrobial usage and antimicrobial resistance (AMR) in animal production is now recognized to be an important contributor to the global problem of AMR. Initiatives to curb indiscriminate antimicrobial use in animal production are currently being discussed in many low- and middle-income countries. Well-designed, scientifically sound interventions aimed to tackle excessive antimicrobial usage ...

Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide f...

Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes, a number of cationic peptides can traverse intact membranes to interact with internal targets.

objective(s):the present study aimed to investigate the antiseptic properties of a colloidal nano silver wound rinsing solution to inhibit a wide range of pathogens including bacteria, viruses and fungus present in chronic and acute wounds. materials and methods:the wound rinsing solution named silvosept® was prepared using colloidal nano silver suspension. physicochemical properties, effective...

antimicrobial activity of different culture extract of oudemansiella sp grown on liquid medium (mygp) were tested. different fungi (c. albicans, c. lipolytica, saccharomyces cervisiea, cladosporium herbarum, and aspergillus niger) and bacteria (microccocus luteus, e. coli, staphylococcus aureus, and staphylococcus epidermidis) were used as test organisms. various antimicrobial assay methods inc...

conclusions this study showed that some properties of antimicrobial substances produced by the ga strain differed from other peptide antibiotics produced by the genus bacillus such as bacitracin, which increases the likelihood of its novelty. results the isolated bacterium was identified as a new strain of bacillus atrophaeus. the antimicrobial substance exhibited heat stability between 25ºc an...

in order to achieve a long-lasting effect, one of the main goals in root canal treatment is to eliminate the endodontic bacteria. conventional chemomechanical debridement is considered as the basic treatment in root canal therapy, but adjunctive techniques such as antimicrobial photodynamic therapy (apdt) can also be helpful. the aim of this study was to evaluate reports in the scientific liter...