The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-d-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa canina by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in r...

T he proinflammatory response of macrophages to stimuli, such as lipopolysaccharide (LPS) or IFN , can be blocked by ligands for peroxisome proliferator-activated receptors (PPARs). However, the mechanisms, and even the validity, of this antiinflammatory role for PPARs has recently come under question. The paper by Welch et al. (1) in this issue of PNAS addresses some of these concerns, and sug...

Vascular injury in acute coronary syndromes (ACS) involves a complex cross-talk between inflammatory mediators, platelets and thrombosis, where the interaction between platelets and coagulation factors (e. g. thrombin) is a central link between thrombosis and inflammation. In ACS, aspirin at antiplatelet doses exhibits anti-inflammatory effects as seen from the decrease in inflammation markers ...