BACKGROUND The purpose of this study was to determine whether seizure susceptibility due to antihistamines is provoked in patients with febrile seizures. METHODS The current descriptive study was carried out from April 2009 to February 2011 in 250 infants and children who visited the Madinah Maternity and Children's Hospital as a result of febrile convulsions. They were divided into two group...

patients with allergic rhinitis (ar) show increased production of the th2-related cytokines. almost always, intranasal corticosteroid (inc) and antihistamine are used as routine therapy of ar. this study was performed to determine the in vitro secretion of cytokines profiles of pbmcs in patients with ar sensitive to chenopodium album (ch.a) pollens before and after treatment with inc (fluticaso...

The ideal antihistamine would optimize both receptor and clinical pharmacology, combining high receptor affinity, reflected by high potency, with outstanding clinical efficacy. Because the basic concepts of potency and efficacy are often confused and used interchangeably within the scientific and pharmaceutical industry, the distinction between these 2 terms must be understood in order for them...

Ocular symptoms often accompany allergic rhinitis and can be as or even more bothersome for the patient than the actual nasal symptoms. Ocular manifestations of allergic rhinoconjunctivitis may result from both direct allergen-mediated mast cell stimulation on the surface of the eye and naso-ocular reflexes--histamine being one of the mediators of symptoms onset. An H1 antihistamine would be th...

Objective: We aim to assess the influence of antihistamines as an adjunctive therapy in children with JIA who also have co-existing mild to moderate AR. Methods: Fifty-two JIA patients with AR were enrolled and consecutively randomized. The control group comprised 26 patients who were treated with methotrexate (MTX) 10-15 mg/m2/week orally for 12 months and enteric-coated diclofenac sodium 0.5-...

novel dispersive liquid-liquid microextraction (dllme), coupled with high performance liquid chromatography with photodiode array detection (hplc-dad) has been applied for the extraction and determination of cyproheptadine (cph), an antihistamine, in human urine samples. in this method, 0.6 ml of acetonitrile (disperser solvent) containing 30 µl of carbon tetrachloride (extraction solvent) was ...

Allergic rhinitis is a common disease with a lifetime prevalence of 20% among the United States population. The cost of medication alone to manage allergic rhinitis in the United States was estimated to be $3.1 billion. The two most commonly prescribed classes of medications are antihistamines and topical nasal steroids. The data on comparing the efficacy of a commonly used antihistamine (azela...