The methanolic extract of fruit of Benincasa hispida (BHFE) was evaluated for its antidiarrheal potential against several experimental models of diarrhea in rats. BHFE treated animals showed significant inhibi-tory activity against castor oil induced diarrhea and inhibited PGE2 induced enter pooling in rats. It also showed significant reduction in gastro intestinal motility following charcoal m...

Theobroma cacao is an economically important tropical-fruit tree where chocolate obtained, and it used as traditional medicine worldwide against several diseases. In the present study, in vivo model computational biology approaches were to elucidate potential mechanisms of T. in treatment diarrhea. The antidiarrheal intestinal motility activity was conducted using animal induce...

OBJECTIVES Mentha longifolia L. (Lamiaceae) is an annual herb that is used in the Iranian traditional medicine for treating stomach and intestinal disorders. The purpose of this study was to determine the protective effect of M. longifolia on experimental diarrhea in a rat model. MATERIALS AND METHODS The antidiarrheal activity of essential oil of M. longifolia (20-80 mg/kg) was investigated ...

Ixora coccinea Linn (Rubiaceae), a small shrub cultivated throughout India, has been reported to possess a number of medicinal properties. It has traditionally been used for the treatment of diarrhea and dysentery. However the claims of Ayurveda have to be validated by suitable experimental models. The present study was therefore undertaken to evaluate the effect of aqueous extract of I. coccin...

High-conductance apical K+ (BK) channels are present in surface colonocytes of mammalian (including human) colon. Their location makes them well fitted to contribute to the excessive intestinal K(+) losses often associated with infective diarrhea. Since many channel proteins are regulated by phosphorylation, we evaluated the roles of protein kinase A (PKA) and phosphatases in the modulation of ...

Aegle marmelos has been used as antidiarrheal, antibacterial and antifungal agent in Unani system of medicine. The plant is highly used by the rural and tribal people for the treatment of diseases. However, despite its traditional usage as an antidiarrheal, antibacterial and antifungal agent, there is limited information regarding its uses in different diseases. The present article enumerates v...

Background: Diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. A popular alternative is probiotics, which have been used in several gastrointestinal disorders. Probiotics are live microbial food supplements. Furthermore, honey is a putative nutritional with a variety of health effects, ...