The antidiabetic and antioxidant activity of Ecbolium ligustrinum (family:Acanthaceae) was investigated in alloxan induced diabetic albino rats. A comparison was made between both plant extracts and a known antidiabetic drug Glibenclamide (5mg/kg body weight). The dried flowers of Ecbolium ligustinum was subjected to extraction by continuous hot extraction method using hydroalcohol and chlorofo...

BACKGROUND Some Ficus species have been used in traditional African medicine in the treatment of diabetes. The antidiabetic potential of certain species has been confirmed in vivo but the mechanism of activity remains uncertain. The aim of this study was to determine the activity and to investigate the mechanism of antidiabetic activity of ten selected Ficus species through inhibition of α-amyl...

The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in para...

The root of Combretum dolichopetalum (Combreatacea) is used in ethnomedicine for the management of diabetes mellitus. Though some compounds have been isolated from it, the antidiabetic principles have not been identified. The present study was designed to evaluate the chemical constituents from the root of C. dolichopetalum with a view to identifying the antidiabetic principles. The constituent...

The aim of present review is to establish the use of plants, plant parts or extract in curing Diabetes mellitus. It also collates available data on plants with hypoglycemic effects. In the present investigation, interest is focused on experimental studies performed on hypoglycemic plants and their bioactive components. A brief description is given about the, type of diabetes, related physiologi...

The aim of this research was to investigate antidiabetic activity of Costus igneus (also known as insulin plant) leaves extracts in streptozotocin induced diabetic albino rats. A comparison was made between the action of Costus igneus extract and a known antidiabetic drug glibenclamide (5mg/kg body wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. Eth...

Diuretics are the agents which cause increase in excretion of urine. Diabetes mellitus (DM) is a multi-factorial disorder characterized by hyperglycemia resulting from an increased hepatic glucose production and diminished insulin secretion. The present study was undertaken to study the diuretic and anti-diabetic activity of esculin. Esculin was found to have potent diuretic activity in normal ...

In view of alleged antidiabetic potential, effect of the petroleum ether, methanol, and aqueous extracts of Terminalia catappa Linn (combretaceae) fruit, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the three extracts of Terminalia catappa produced a significant antidiabetic activity at dose levels 1/5 of their lethal doses...

Thiadiazole compounds have versatile activities such as anti-microbial, anti-inflammatory, anticancer, etc. Present study involves design of thiadiazole compounds as antidiabetic agent using docking studies. The designed molecules were synthesized and subjected to antidiabetic activity by in vitro and in vivo method. Compound TD7 was found to show potent antidiabetic activity in alloxan induced...

The antidiabetic activities of bitter melon powders produced with lyophilization/superfine grinding and hot air drying/normal grinding were investigated in vivo for selecting a suitable bitter melon processing procedure. After a five-week treatment, bitter melon lyophilized superfine grinding powder (BLSP) had a higher antidiabetic activity with reducing fasting blood glucose levels from 21.40...