Three series (series A-C) of coumarin analogues with phenylpiperazine functions as substitution were designed and synthesized for studying their potential for treating Alzheimer's (AD) disease. Their anticholinesterase activities were assayed according to Ellmann's method against freshly prepared acetylcholinesterase (AChE) from Electrophorus electricus using donepezil as the reference compound...

Objective: A new series of 4-[3-(substitutedphenyl)thioureido]-N-(6-chloropyrazin-2-yl)benzenesulfonamide were synthesized from sulfaclozine. Methods: All compounds characterized by IR, 1H-NMR spectroscopic methods and elemental analysis. In addition to the antioxidant activity synthesis series, enzyme inhibition activities such as anticholinesterase, tyrosinase, ?-amylase ?-glycosidase determi...

Congenital or hereditary myasthenia describes a heterogeneous group of disorders in which the immune system is not implicated. Treatment has previously depended on anticholinesterase medication. The effectiveness of 3,4-diaminopyridine (3,4-DAP), a preparation that enhances acetylcholine release from motor nerve terminals, has been evaluated using a series of standardised strength measures. Six...

Ganguly, J., Krinsky, N. I. & Pinchard, J. H. (1956). Arch. Biochem. Biophy8. 60, 345. Goodwin, T. W. (1952). The Comparative Biochemi8try of the Carotenoid8. London: Chapman and Hall. Goodwin, T. W. (1955). Analy8is of Carotenoid8. In Handbook of Plant Analy8i8, vol. 3, p. 272. Ed. by Paech, K. & Tracey, M. V. Heidelberg: Springer. Goodwin, T. W. & Morton, R. A. (1946). Analy8t, 71, 15. Goodwi...

A total of 30 chloroform and methanol extracts from the following endemic Soqotran plants Acridocarpus socotranus Olive, Boswellia socotranao Balf.fil, Boswellia elongata Balf. fil., Caralluma socotrana N. Br, Cephalocroton socotranus Balf.f, Croton socotranus Balf. fil.., Dendrosicycos socotrana Balf.f., Dorstenia gigas Schweinf. ex Balf. fil., Eureiandra balfourii Cogn. & Balf. fil., Kalancho...

the present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of hypericum retusum aucher. the amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by hplc. total phenolic content of h. retusum seed extract was found more than fru...

The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten derivatives were synthesized and evaluated for inhibitory activities against acetylcholinesterase (AChE) butyrylcholinesterase (BChE) by Ellman’s method. Most tested showed higher on BChE than AChE, however, their overall activity weak. In contrast, three (compounds 3,6,9) good AChE m...