The effects of 4-aminopyridine (a non-anticholinesterase antagonist of curare-like agents) on the evoked muscle action potentials (EMAP) in a patient with Eaton Lambert Syndrome are reported. On two separate occasions the i.v. administration of 0.31 mg kg(-1) and 0.62 mg kg(-1) was followed by a 300% increase of EMAP for about 2 h without serious side-effects.

1. The adipokinetic hormone release, which can be induced by anticholinesterases, is reduced by depleting the content of monoamines in the nervous system. 2. The participation of monoamines in the pathway of release of adipokinetic hormone is studied in vivo and in vitro. 3. A possible mechanism for anticholinesterase-induced release of this hormone involving cholinergic and aminergic transmiss...

AIMS To document the patterns of presentation and outcome of severe anticholinesterase insecticide poisoning in children requiring intensive care. METHODS Retrospective case note review of all 5541 children admitted to the paediatric intensive care unit (PICU) of a university hospital during the 10 years from January 1990 to May 2000. Fifty four children (1%) with anticholinesterase insectici...

Diisopropylfluorophosphonate (DFP) is a drug which has been made available for physiological and pharmacological investigation as a result of researches carried out on the alkylfluorophosphonates by McCombie and Saunders (1946) for the Ministry of Supply. The anticholinesterase action of these compounds was recognized in 1941 by Adrian, Feldberg, and Kilby (1947). Later, Mackworth and Webb (194...

BACKGROUND Based on the pharmacological potency and structural features of succinimides, this study was designed to synthesize new ketoesters derivatives of succinimides. Furthermore, the synthesized compounds were evaluated for their possible anticholinesterase and antioxidant potentials. The compounds were synthesized by organocatalytic Michael additions of α-ketoesters to N-aryl maleimides. ...

The organophosphorus and carbamate insecticides inhibit cholinesterase, causing an increase of acetylcholine at neuromuscular junctions. Toxicosis due to anticholinesterase compounds can be diagnosed by finding depressed cholinesterase activity in the blood, brain, and/or retina. Cholinesterase activity < 50% of normal has been associated with significant exposure to an anticholinesterase agent...