Sodium-glucose cotransporter 2 (SGLT2) serves as a critical glucose transporter that has been reported to be overexpressed in cancer models, followed by increased uptake both mice and humans. Inhibition of its expression can robustly thwart tumor development vitro vivo. SGLT2 inhibitors are comparatively new class antidiabetic drugs have demonstrated anticancer effects several malignancies, inc...

Natural Anticancer Agents Cancer is the second leading cause of death throughout world. In article number 2209419, Hadis Rostamabadi and co-workers, comprehensively overview biopolymer nanovehicles for oral delivery natural anticancer agents (NAAs). NAAs that are a gift nature to humanity, have been extensively utilized in alleviation/prevention cancer. The restricted by some inherent features ...

Cancer is a leading cause of death worldwide. Many heterocyclic cores are present in the structures of clinically approved anticancer drugs. Meanwhile, benzothiazoles have been reported as one of the most important heterocyclic scaffolds in previously reported anticancer agents in the literature. Therefore, in this report, a novel series of 2-phenyl benzothiazole derivatives was synthesized, bi...

Anticancer drug development is facing increasingly challenge. Much more chemicals or bio-agents are required to be evaluated every year. High-quality and speediness of evaluation requires joint-efforts between chemists pharmacologists. This Editorial provides this area anticancer discovery, licensing.

Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A diverse range of drugs used in the treatment of cancer has been associated with radiation recall. As ...

Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Several anticancer agents including taxol, vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world. A number of promising agents such as f...

1,072,503 person-year of follow-up, 195,594 patients died: 162,067 from cancer, 14,489 from cardiovascular causes and 19,038 from other causes. Among patients, 40 years and older, 18,721 received statins before cancer diagnosis and 277. 204 had never used statins. All cause mortality among patients with cancer taking statins was reduced by 15%, and only by 10% as risk for death from cardiovascu...

The use of animal toxicology as a potential predictive system for drug toxicity in man is particularly important to the field of cancer chemotherapy because of several major clinical considerations (11). The nature of the growth characteristics of tumors in man requires that repeated courses of treatment be given oven extended periods of time; this approach carries with it an increased risk for...