Despite tremendous progress in understanding the nature of the immune system, the full diversity of an organism's antibody repertoire is unknown. We used high-throughput sequencing of the variable domain of the antibody heavy chain from 14 zebrafish to analyze VDJ usage and antibody sequence. Zebrafish were found to use between 50 and 86% of all possible VDJ combinations and shared a similar fr...

Data from 247 global software development teams were used to examine the impact of temporal dispersion and leadership roles on the relationship between nationality diversity and team performance. Nationality diversity was positively related to team performance when project leaders regularly coordinate and monitor team members’ activities, and acted as mentors and facilitator. However, when nati...

BACKGROUND The extraordinary diversity characterizing the antibody repertoire is generated by both evolution and lymphocyte development. Much of this diversity is due to the existence of immunoglobulin (Ig) variable region gene segment libraries, which were diversified during evolution and, in higher vertebrates, are used in generating the combinatorial diversity of antibody genes. The aim of t...

An improved immune cloning algorithm based on clustering competition is proposed, which ensures the diversity of antibody population, effectively improves convergence speed and avoids immature convergence. The applied to packing problem achieves good results.

Community structure has been widely identified as a feature of many real-world networks. It has been shown that the antigenic diversity of a pathogen population can be significantly affected by the contact network of its hosts; however, the effects of community structure have not yet been explored. Here, we examine the congruence between patterns of antigenic diversity in pathogen populations i...