aims: cholera is an acute diarrheal disease that can lead to severe dehydration and death. antibiotic resistance is a big challenge in infective disease like cholera. the present study aimed to understand the characteristics and trends of antibiotic resistance of v. cholerae isolations in and around kashan, iran. instrument & methods: in this descriptive cross-sectional study, samples were gath...

BACKGROUND The emergence of multiple-drug resistance bacteria has become a major threat and thus calls for an urgent need to search for new effective and safe anti-bacterial agents. OBJECTIVES This study aims to evaluate the anticancer and antibacterial activities of secondary metabolites from Penicillium sp., an endophytic fungus associated with leaves of Garcinia nobilis. METHODS The cult...

the present study aimed to evaluate the antimicrobial activity of a hetroalkyl oximec synthetic compoundderivative (benzophenone o-4-bromoethyl oxime) against two gram positive and three gram negative bacteria.the antibacterial characteristic of this compound was shown using the circular zone diameter of bacterial growthinhibition by disk-diffusion method. in addition, the random amplified poly...

The Infectious Diseases Society of America (IDSA) continues to view with concern the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those caused by gram-negative pathogens. Infections now occur that are resistant to all current antibacterial options. Although the IDSA is encouraged by the prospect of success for some agents currently in preclinical developme...

BACKGROUND Quinolone resistance in Enterobacteriaceae species has increased over the past few years, and is significantly associated to beta-lactam resistance. The aim of this study was to evaluate the prevalence of chromosomal- and plasmid-mediated quinolone resistance in acquired AmpC β-lactamase and/or carbapenemase-producing Enterobacteriaceae isolates. METHODS The presence of chromosomal...

Berberine-INF55 hybrids are a promising class of antibacterials that combine berberine and the NorA multidrug resistance pump inhibitor INF55 (5-nitro-2-phenylindole) together in one molecule via a chemically stable linkage. Previous studies demonstrated the potential of these compounds for countering efflux-mediated antibacterial drug resistance but they didn't establish whether the compounds ...

The antibacterial therapeutic area has been described as the perfect storm. Resistance is increasing to the point that our hospitals encounter patients infected with untreatable pathogens, the overall industry pipeline is described as dry and most multinational pharmaceutical companies have withdrawn from the area. Major contributing factors to the declining antibacterial industry pipeline incl...

background: infection with non-typhoid salmonella (nts) is one of the most important health problems all over the world. antimicrobial drug resistance is increasing among salmonella infantis species. objectives: the aim of this study was to investigate the frequency of presence of class 1 integrons in s. infantis species as well as its association with drug resistance. materials and methods: th...

the increasing incidence of multi drug resistance tuberculosis (mdr-tb) and extensively drug resistance tb (xdr-tb) worldwide highlight the urgent need to search for newer anti-tuberculosis compounds. it has been determined that pharmaceutical plant, hops ( humulus lupulus ), possesses some antibacterial effect. in this study, the antimycobacterial effect of this plant on rifampin sensitive and...

BACKGROUND The rising drug resistance in pathogenic bacteria and inefficiency of current antibiotics to meet clinical requirements has augmented the need to establish new and innovative approaches for antibacterial drug discovery involving identification of novel antibacterial targets and inhibitors. Being obligatory for bacterial growth, essential gene products are considered vital as drug tar...