Salicylate has previously been shown to reduce the susceptibility of Mycobacterium tuberculosis to several drugs in vitro. In this study, aspirin, a salicylate anti-inflammatory, antagonized isoniazid treatment of murine pulmonary tuberculosis, whereas the nonsalicylate ibuprofen did not. These results may have implications on concurrent administration of anti-inflammatory and antituberculosis ...

Objective: Psoriasiform drug eruptions can be induced by several drugs. Psoriasis is a chronic inflammatory disease characterized T-cell-mediated cytokine production that drives the hyperproliferation and abnormal differentiation of keratinocytes. Drugs cause new lesions when there no prior history or family psoriasis. Based on psoriatic eruption probability score, β‐blockers, synthetic anti‐ma...

extrapulmonary tuberculosis is a complication of pulmonary tuberculosis that is disseminated through hematogenous or lymphatic system and may involve any organs. we present a case of primary tuberculosis of the penis that is a very rare presentation of tuberculosis. patient the patient was a 43-year-old man who had kidney transplantation. he admitted with painful ulceration on the glans of peni...

he resurgence of drug resistant tuberculosis and HIV associated intractable mycobacterial infection are of serious global concern. This is due to their potential to survive dormantly in a nonreplicating state in protective intracellular niches of Macrophages, dendritic cells, epithelial cells, endothelial cells, fibrocytes, adipocytes and bone marrow stem cells. To contain this situation, new a...

To evaluate the genetic damage induced by tuberculosis infection and also by a combination of therapeutic exposure to anti-tuberculosis (anti-TB) drugs (isoniazid + rifampicin + pyrazinamide + ethambutol or streptomycin) we have considered chromosome aberrations (CA) and micronuclei (MN) in binucleate peripheral blood lymphocytes from 36 patients diagnosed with pulmonary tuberculosis prior to r...

efficient tuberculosis treatment requires the use of good quality medicines. the present study developed a method of dosage by high performance liquid chromatography (hplc) coupled with the dissolution of a combination of fixed doses of four anti-tuberculous (isoniazid, pyrazinamide, ethambutol hydrochlorate, rifampicine). the elaborated protocol was thereafter used to assess the quality of med...

A case of Mycobacterium avium arthritis in a 39-year-old female patient with mixed connective tissue disease (MCTD) was reported. An extra-articular abscess had formed outside the knee joint and extended down the calf. A culture was taken of the abscess and synovial fluid disclosed Mycobacterium avium. This was resistant to most anti-tuberculosis agents. A combination of anti-tuberculosis drugs...