Discovery of quorum sensing (QS) system to coordinate virulence and biofilm formation in bacterial pathogens has triggered search for safe, stable and non-toxic anti-QS compounds from natural products. Ethanolic extracts of 24 Indian medicinal plants were tested by agar well and disc diffusion assay for anti-QS activity using Chromobacterium violaceum (CV12472 and CVO26) reporter strains. AHL f...

Euphorbia trigona latex has been used most effectively in the traditional Indian medicinal system of Ayurveda for the treatment of urinary tract infection (UTI). However, various organic and aqueous extracts of its latex were found not to possess any antimicrobial activity against several gram positive and gram negative organisms including Proteus mirabilis and Pseudomonas aeruginosa (selected ...

Recently, misuse or overuse of antibiotics has led to the antibiotic resistance problem, a global healthcare problem. Most virulence factors and biofilm formation in Pseudomonas aeruginosa are controlled by quorum sensing (QS). The inhibition QS system inhibitor molecules been suggested as novel alternative antivirulence approach which no need kill bacteria. In present study, inhibitory potenti...

INTRODUCTION The term quorum sensing (QS) is used to describe communication between bacterial cells, whereby a coordinated population response is controlled by diffusible signal molecules produced by individuals. SOURCES OF DATA Studies on QS-mediated signalling processes in bacteria have revealed the existence of intricate regulatory networks to enable bacterial populations to fine tune thei...

OBJECTIVES The aim of this study was to evaluate the association between two semi-quantitative Doppler US scoring systems (SQS), and the quantitative scoring (QS) of Doppler pixel count. METHODS Adult patients with RA and inadequate clinical response to anti-rheumatic therapy were examined with musculoskeletal US (MSUS). Dorsal MSUS of the wrists, MCP and MTP 2-5 were performed. MSUS images w...

Bacteria form a biofilm that attaches the microbial population to solid surface, thus acting as barrier protect external stresses from bacterial community. In food industry, biofilms are believed be responsible for food-borne diseases and spoilages. This research was conducted characterize anti-quorum sensing (QS), anti-biofilm activity of crude extract, supernatant Actinobacteria isolates agai...

Quorum sensing (QS) systems communicate bacterial population and stimulate microbial pathogenesis through signaling molecules. Inhibition of QS signals potentially suppresses microbial infections. Antimicrobial properties of Streptomyces have been extensively studied, however, less is known about quorum sensing inhibitory (QSI) activities of Streptomyces. This study explored the QSI potential o...

Pseudomonas aeruginosa defies eradication by antibiotics and is responsible for acute and chronic human infections due to a wide variety of virulence factors. Currently, it is believed that MvfR (PqsR) controls the expression of many of these factors indirectly via the pqs and phnAB operons. Here we provide strong evidence that MvfR may also bind and directly regulate the expression of addition...

Sansevieria trifasciata is a plant that commonly utilized in traditional medicine. The leaves of S. show antibacterial properties against Pseudomonas aeruginosa. This bacterium an opportunistic pathogen can cause serious illness humans and produce variety virulence factors responsible for bacterial pathogenesis with quorum sensing (QS) systems mediate intracellular communication. Bacteria prote...

Pseudomonas aeruginosa is an opportunistic pathogen that orchestrate its disease manifestation via a complex communication system known as quorum sensing (QS). Under the regulation of this network QS system, myriad virulence factors including flagella and pili contribute to motility. To establish infection in host, P. must first attach itself host cells with assistance it would be mere impossib...