Epilepsy affects 5 to 10 per 1000 of the general population. It is the third most common neurological disorder after stroke and Alzheimer's disease. Available anti-convulsant drugs effectively control epilepsy in about 50% of the patients. Many epileptic seizures are refractory to current anti-epileptic drugs and safety of the anti-epileptic drugs has always been a concern. Herbal drugs may ser...

Background: Epilepsy is a common chronic neurological disorder with more than half of cases beginning in childhood. Most patients require long-term, and sometimes life-long, therapy antiepileptic drugs (AEDs). AEDs are associated significant side effects including radiological evidence rickets, decreased bone mineral density (BMD), altered turnover, increased risk fracture.
 Aim the Study:...

Neuropathic pain is a disabling chronic condition. Current international guidelines for the management of neuropathic pain include the use of anti-depressants and anti-epileptic medications, including amitriptyline (tricyclic anti-depressants), duloxetine (serotonin noradrenaline reuptake inhibitor), gabapentin (antiepileptic) and pregabalin (anti-epileptic) [1]. Opioids are mentioned but the g...

lamotrigine is a safe anti-epileptic drug among pregnant and lactating women. some concerns exist regarding the safety of lamotrigine during breastfeeding and related neonatal complications. in this brief review, this matter was evaluated and discussed. in this review study, the medical literature available in search databases such as embase, scopus, pubmed, and medline and even also local medi...

575 IntroductIon Anti-epileptic medications can be divided into two major groups. The traditional antiepileptic drugs, which were released for use prior to 1978, are Phenobarbital, Phenytoin, Primidone, Clonazepam, Ethosuximide, Carbamazapine and Valproate. There was a 15-year period from 1978 to 1993, when no new antiseizure drug was approved for use. Since 1993, an additional eight new anti-e...

Aetna considers vagus nerve electrical stimulators medically necessary durable medical equipment (DME) for shortening the duration or reducing the severity of seizures in members with partial onset seizures who remain refractory to optimal anti-epileptic medications and/or surgical intervention, or who have debilitating side effects from anti-epileptic medications. (Note: Electronic analysis of...

Trace elemental analysis was carried out in 15 anti-epileptic medicinal plants using Energy Dispersive X-Ray Fluorescence (EDXRF) technique, with EX-3600, EDXRF spectrometer. The quantitative analysis is carried out using the software nEXT. The concentrations of elements like P, S, Cl, K, Ca, Mn, Fe, Cu, Zn, Br, Se, Rb, and Sr were estimated. The presence of some of these trace elements is corr...

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are two rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions and mucous membrane erosions. Anti-epileptic drugs are highly suspected to be the causative agents. Although carbamazepine (CBZ) is the most associated anti-epileptic drug, oxcarbazepine (OXC), which is a monohydrated derivative ...

Background Seizures are a considerable complication in critically ill patients. Their incidence is significantly high in neurosciences intensive care unit patients. Seizure prophylaxis with anti-epileptic drugs is a common practice in neurosciences intensive care unit. However, its utility in patients without clinical seizure, with an underlying neurological injury, is somewhat controversial. ...

It has been hypothesized that tinnitus is a form of sensory epilepsy, arising partly from neuronal hyperactivity in auditory regions of the brain such as the cochlear nucleus and inferior colliculus. Although there is currently no effective drug treatment for tinnitus, anti-epileptic drugs are used in some cases as a potential treatment option. There is increasing evidence to suggest that canna...