Formation of biofilm in pathogenic bacteria defends them from antibiotics and the immune system of a host's life. Hence, investigation of the molecular mechanisms of biofilm formation and search for new substances counteracting this formation are becoming an attractive research area. In the course of our search for new inhibitors of biofilm formation in Mycobacterium species, we rediscovered a ...

BACKGROUND & OBJECTIVES Ciprofloxacin is commonly used in clinical practice for the treatment of recurrent urinary tract infections caused by Escherichia coli. However, very often these recurrent infections are due to a failure in a complete eradication of the microorganisms colonizing the urinary tract, especially in catheterized patients. To enhance the bactericidal activity of ciprofloxacin ...

objective(s):serratia marcescens is one of the nosocomial pathogen. the ability to form biofilm is an important feature in the pathogenesis of s. marcescens. the aim of this study was to determine the anti-adhesive properties of a biosurfactant isolated from lactobacillus acidophilus atcc 4356, on s. marcescens strains. materials and methods: lactobacillus acidophilus atcc 4356, was selected as...

objective: microorganisms are responsible for many problems in industry and medicine because of biofilm formation. therefore, this study was aimed to examine the effect of thymus vulgaris (t. vulgaris) extracts on the planktonic form and biofilm structures of six pathogenic bacteria. materials and methods: antimicrobial activities of the plant extracts against the planktonic form of the bacteri...

P. aeruginosa has been mentioned as the major causative agents of nosocomial infections. Pseudomonas infections are often serious and show different resistance to treatment due to distribution of antimicrobial resistance. Meanwhile, some strains are also able to form biofilm during contamination, which help bacteria to be even more persisyant to yreatment. We examined the antibiotic resistance ...

In this paper, we report the design of a new nanofluid for anti-pathogenic surface coating. For this purpose, new 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl)-benzamides were synthesized and used as an adsorption shell for Fe3O4/C12 core/shell nanosized material. The functionalized specimens were tested by in vitro assays for their anti-biofilm properties and biocompatibility....

Histophilus somni is an opportunistic pathogen causing respiratory, genitourinary and generalized infections in cattle. An important virulence factor is its ability to produce a biofilm. The aim of this work was to confirm that H. somni Hsp60 (Gro-EL) is a constituent of the biofilm produced by this bacterium in vitro and to check whether or not the presence of a specific antibody within the cu...

When single-cell (or suspended) bacteria switch into the biofilm lifestyle, they become less susceptible to antimicrobials, imposing the need for anti-biofilms research. Flavonoids are among the most extensively studied natural compounds with an unprecedented amount of bioactivity claims. Most studies focus on the antibacterial effects against suspended cells; fewer reports have researched thei...

Anti-Planktonic and Anti-Biofilm Formation Activities of the Essential Oil Hydroalcoholic Extract Myrtus communis L. Leaves Fruits Against Clinical Candida species

BACKGROUND Staphylococcus aureus in its biofilm form has been associated with recalcitrant chronic rhinosinusitis with significant resistance to conventional therapies. This study aims to determine if liposomal-encapsulation of a precursor of the naturally occurring antimicrobial nitric oxide (NO) enhances its desired anti-biofilm effects against S. aureus, in the hope that improving its effica...