Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in presence hydroxylamine hydrochloride. Isoxazoline is an important class nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active have been using it intermediate. D...

Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...

Biofilm formation can lead to problems in healthcare, water distribution systems, food processing and packaging, industrial manufacturing, marine industries, sanitation. These microbial communities proliferate on biotic or abiotic surfaces, are responsible for human disease decreasing production efficiency service equipment life many fields. The of biofilm starts with the attachment bacteria su...

Studies were made on the effects of in vivo administration of anti-CD4 mAb, anti-CD8 mAb, or a combination of both mAbs on multiplication of bacteria, the levels of serum transaminases, and mortality in mice infected with Listeria monocytogenes. Results showed that in sublethal infection, CD8+ cells enhanced the peak of bacterial multiplication and liver cell necrosis, and CD4+ cells suppressed...

PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesi...

Herein we reported the development of aptamer-based biosensors (aptasensors) based on label-free aptamers and gold nanoparticles (AuNPs) for detection of Escherichia coli (E. coli) O157:H7 and Salmonella typhimurium. Target bacteria binding aptamers are adsorbed on the surface of unmodified AuNPs to capture target bacteria, and the detection was accomplished by target bacteria-induced aggregati...

Abstract Introduction: The aim of this study was to identify the antibacterial components in the ethanol extraction of Aloe vera against four clinically frequent pathogenic  bacteria. Materials and Methods: In this in-vitro study, Aloe vera extraction was prepared by dissolving 500 grams of the powder in 5L of 95% ethanol. The antibacterial activity of the extraction against Staphylococcus a...