The optic neuritis of systemic lupus erythematosus (S.L.E.) more frequently results in the persistence of a central scotoma or complete blindness after a single attack than demyelinating optic neuritis, although the initial clinical presentations may be identical. A significant number of patients, however, recover normal vision. Optic neuritis may be the presenting symptom of S.L.E. and as myel...

The commonest cause of an optic neuropathy in Singapore is ischaemia, and ischaemic optic neuropathy (ION) is one of the commonest causes of permanent loss of vision in elderly patients, especially in those with diabetes mellitus, hypertension and hyperlipidaemia. ION in our practice is almost invariably of the anterior variety and non-arteritic in origin, i.e. NA-AION. Posterior ION comprises ...

PURPOSE To report two cases of optic neuritis with onset less than 24 hours following measles-rubella (MR) vaccination. CASE REPORT Two teenage patients developed acute optic neuritis 6 to 7 hours after MR booster vaccination. The first patient demonstrated bilateral papillitis and severe visual loss but improved significantly with pulse intravenous steroid therapy with methylprednisolone 500...

In order to understand the vision of patients with long standing optic neuritis, contrast perception was analysed in some detail for three patients with uniocular anomalies. Contrast detection and contrast matching experiments each demonstrate anomalies in contrast processing for eyes with optic neuritis. In this regard, optic neuritis differs from all other visual anomalies so far investigated...

Demyelinating optic neuritis is the commonest cause of optic neuropathy in young adults. Retrobulbar optic neuritis is one of the frequent clinical forms of demyelinating optic neuritis. We report a case of a 28-year-old lady who presented with blurring of vision in the right eye for one month and pain on eye movement. Fundi examinations were normal. Initial suspicion was that of retrobulbar op...

Monosymptomatic unilateral optic neuritis is a common first manifestation of multiple sclerosis. Abnormal T cell responses to myelin components including myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associated glycoprotein (MAG) have been implicated in the pathogenesis of multiple sclerosis. Antigen-reactive T helper type 1 (Th1)-like cells that responded by interferon gamm...

T HE INVESTMENT of the National Eye Institute in the Optic Neuritis Treatment Trial continues to pay dividends. In this issue of the ARCHIVES, the Optic Neuritis Study Group reports on the risk of developing multiple sclerosis (MS) after an attack of isolated optic neuritis. This issue is of great importance to patients and physicians and, as the authors acknowledge, has been addressed in prior...

To cite: Mendonca N, Shah AJ, Saldanha M, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-204631 DESCRIPTION Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic inflammatory demyelinating disease that usually presents in children and young adults after viral infection. It is thought to be an autoimmune disorder of the central nervous...

PURPOSE To report the clinical features and outcome of a series of children with optic neuritis. METHODS We reviewed the medical records of patients up to 16 years old with optic neuritis. Group 1 comprised children seen up to two weeks after the onset of visual loss; Group 2 comprised patients already harboring optic atrophy. RESULTS There were 15 boys and 12 girls. The mean age was 10.9 y...