the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

Fungi are the most important phytopathogens that cause yield losses. The mycotoxins released by fungi spoilage of stored food consumed humans and feed supplied to animals. Fungi-antagonistic microbes gaining attention as potential biocontrol agents (BCAs). This study was designed isolate bacterial isolates from different crops evaluate their in vitro antifungal assay against three phytopathogen...

Lentil collar rot disease caused by Sclerotium rolfsii Sacc. is an important causing significant yield loss in Nepal. Seven Trichoderma spp. isolates collected from different regions of Nepal were tested for their capacity to inhibit mycelial growth in-vitro condition. Experiment was conducted Completely Randomized Design with four replications the plant pathology laboratory Grain Legumes Resea...

Anticancer drug combinations can act synergistically or antagonistically against tumor cells in vitro depending on the ratios of the individual agents comprising the combination. The importance of drug ratios in vivo, however, has heretofore not been investigated, and combination chemotherapy treatment regimens continue to be developed based on the maximum tolerated dose of the individual agent...

The investigation was carried out at the laboratory of Plant Pathology Department, SASRD, Nagaland University (NU), Medziphema Campus, Nagaland, India during year kharif (August-October, 2020) to evaluate antagonistic potentiality Trichoderma spp. (T. harzianum, T. asperellum and virens) against three diseases pigeonpea viz. Alternaria leaf spot (Alternaria alternata), Collar rot (Sclerotium ro...

Trichoderma species are among important antagonists of plant pathogenic fungi. The main purpose of this study was to evaluate the biocontrol potential of native Trichoderma spp. isolates from sugar beet fields against Phytophthora drechsleri and P. cryptogea, the causal agents of Phytophthora root rot of sugar beet. During 2007–08, 85 isolates of Trichoderma spp. from sugar beet fields in eight...

Various formulations of selenium and vitamin E, both essential human dietary components, have been shown to possess a therapeutic and preventive effect against prostate cancer. Fortuitous results of clinical trials also implied a risk-reduction effect of selenium and vitamin E supplements. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), using oral selenium and vitamin E supplementa...

Cathepsin S is a cysteine protease highly expressed in many type of cancers including colorectal, prostate, breast, and glioblastoma’s. It is involved in tumor progression through extracellular matrix remodeling. In recent years, antibody research specifically targeting Cathepsin S to block/inhibit tumorigenic effects were generated some positive preclinical data. This antagonistic antibody was...