To examine the role of angiotensin II in the maintenance of blood pressure and the control of aldosterone secretion in man, eight normal subjects were studied on a tilt table in sodium replete and sodium depleted states prior to and subsequent to the intravenous infusion of an angiotensin converting enzyme inhibitor (CEI). In both the sodium replete or sodium depleted state, upright tilting res...

conclusions in conclusion, the ace and pparg genes do not have a key role in conferring risk for diabetic nephropathy. results ace id genotypes followed hardy-weinberg equilibrium in both cases and controls. but p12a genotypes deviated from hardy-weinberg equilibrium in diabetic controls. chi2 test was applied for the analysis of genotypic distributions in genotypic and dominant models. odds ra...

background: spontaneous abortion is considered as the most complex problem during pregnancy. thrombophilia is resumed as a cause of recurrent pregnancy loss (rpl). glycoprotein iiia (gpiiia) gene is involved in thrombosis and abortion. angiotensin converting enzyme (ace) converts angiotensin i to angiotensin ii and is involved in thrombosis. the most common polymorphism in this gene is the inse...

analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. A, Morita H et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Coleman CI et al. Combination therapy with an ACE inhibitor and an...

It has been shown that the renin-angiotensin system (RAS) plays key roles in the inflammation process. Imbalance in the oxidant-antioxidant system is one of the major causes of inflammation. In the present study, the effects of captopril on total and differential WBC, oxidative stress in systemic inflammation produced by lipopolysaccharide (LPS) were investigated. The rats were divided to: cont...

OBJECTIVES This study examined the hypothesis that patients who develop angiotensin-converting enzyme inhibitor intolerance attributable to circulatory-renal limitations (CRLimit) have more severe underlying disease and worse outcome. BACKGROUND Although the renin-angiotensin system contributes to the progression of heart failure (HF), it also supports the failing circulation. Patients with t...

The angiotensin-converting enzyme from rabbit lung was purified to a homogeneous protein. The molecular weight of the enzyme or its subunits in sodium dodecyl sulfate-polyacrylamide gel electrophoresis was established as 180,000. Converting enzyme contained about 8% (w/w) hexoses (based on glucose). The K,,, values for the hydrolysis of angiotensin I and [desAspllangiotensin I by the purified e...

PURPOSE OF REVIEW Several trials demonstrated that angiotensin-converting enzyme inhibitors reduce the incidence of cardiovascular events during long-term follow-up in high-risk and low-risk patients. Clinical treatment guidelines propose that angiotensin-converting enzyme inhibitors should be considered in the routine secondary prevention in the broad group of coronary artery disease patients....

Angiotensin-converting enzyme (ACE) plays an important role in regulating blood pressure the body by converting angiotensin-I into angiotensin-II. It is basic component of Renin angiotensin aldosterone system (RAAS), imbalance RAAS may leads to many cardiovascular and renal diseases. There are marketed available drugs for inhibition ACE, but prolonged use some cause progressive side effects. Re...