Coronary stenting is routinely utilized to treat symptomatic obstructive coronary artery disease. However, the efficacy of bare metal coronary stents has been historically limited by restenosis, which is primarily due to excessive neointima formation. Drug-eluting stents (DES) are composed of a stainless steel backbone encompassed by a polymer in which a variety of drugs that inhibit smooth mus...

BACKGROUND Although stents reduce restenosis compared with balloon angioplasty, their long-term efficacy is limited by neointimal hyperplasia. Platelet and alpha(v)beta(3) integrin receptor inhibition limits neointimal proliferation in animal models of arterial injury. METHODS AND RESULTS We tested whether the dual beta(3) integrin blocking agent abciximab, administered for 12 or 24 hours at ...

BACKGROUND Drug-eluting stents have shown promising antirestenotic effects in clinical trials. Non-stent-based local delivery of antiproliferative drugs may offer additional flexibility and also reach vessel areas beyond the immediate stent coverage. The aim of the present study was to evaluate a novel method of local drug delivery based on angioplasty balloons. METHODS AND RESULTS Stainless ...

In 1995, a total of 278 982 percutaneous coronary interventions were carried out in Europe alone. In the United States, the corresponding figure for the same period was approximately 500 000, and these figures continue to increase worldwide, year after year. To date, plain old balloon angioplasty remains the strategy of choice in the majority of cases, even though a myriad of different devices ...

When Andreas Grüntzig performed the first percutaneous transluminal coronary angioplasty in 1978, he did not expect that this procedure would become one of the most often performed interventions in medicine worldwide. The Achilles’ heels of balloon angioplasty were early reocclusions and restenosis. However, .60% of the patients after plain old balloon angioplasty did well without any need for ...

OBJECTIVES The safety and long-term results of directional coronary atherectomy in stented coronary arteries were determined. In addition, tissue studies were performed to characterize the development of restenosis. METHODS Directional coronary atherectomy was performed in restenosed stents in nine patients (10 procedures) 82 to 1,179 days after stenting. The tissue was assessed for histologi...

Objective: The purpose of this study was to calculate the incidence in-stent restenosis in patients with DES and stent lengths higher than 30mm who presented a tertiary care hospital. Study Design: A Cross-sectional Place Duration: This cross-sectional conducted at Department Cardiology, Rashid Latif Medical College, Lahore duration from February, 2022 July, 2022. Methods: There were 83 coronar...

The use of drug-eluting stents in clinical practice has altered the treatment perspective for bifurcation lesions; however, relatively high rates of stent thrombosis and restenosis are still observed. All bifurcations are unique; therefore, a crucial issue in bifurcation angioplasty regards the selection of the most appropriate strategy for an individual bifurcation. When stenting is used, a ma...

OBJECTIVES The purpose of this study was to use volumetric intravascular ultrasound analysis of Palmaz-Schatz stents to assess the in-stent restenotic process. BACKGROUND By reducing lesion elastic recoil and chronic arterial remodeling, stents improve the long-term results of coronary angioplasty. However, stents are prone to the development of neointimal hyperplasia. Angiographic studies of...