Colorectal cancer (CRC) aggressiveness is caused by angiogenesis which promotes the growth and metastasis associated with poor prognosis survival. The vascular endothelial factor-A (VEGF-A) its receptor (VEGFR-2) form major signaling pathway in angiogenesis. This study aimed to investigate anti-angiogenesis activity of quercetin both colorectal cells cells. tube formation human vein (HUVECs) wa...

Corneal neovascularization (CoNV), a pathological form of angiogenesis, involves the growth blood and lymph vessels into avascular cornea from limbus adversely affects transparency vision. Alkali burn is one most common forms ocular trauma that leads to CoNV. In this protocol, CoNV experimentally induced using sodium hydroxide solution in controlled manner ensure reproducibility. The alkali mod...

Bone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts osteocytes have precise role in the context endochondral intramembranous ossification. While link between bone tissue, marrow haematopoiesis crucial for generation progenitor forming cells, recent research indicates that physiology as healing, repair regeneration d...

Abstract Bacterial infection and impaired angiogenesis make the treatment of diabetic foot ulcers (DFU) extremely challenging. Cationic polymers are expected to treat infected wounds due their excellent antibacterial properties, but still, it is difficult meet therapeutic needs pro‐angiogenesis anti‐infections simple construction units outmoded synthesis methods. Herein, a cationic poly(pentahy...

objective(s) we investigated the effects of low-dose morphine on nitric oxide (no) and angiogenesis in two-kidney one clip hypertensive (2k1c) rats. materials and methods male rats were divided into two groups: sham-clip operated and 2k1c. each group subdivided into saline and morphine (3 mg/kg i.p. 8 weeks) groups. blood pressure, heart rate, plasma renin activity (pra), no concentration and m...

background: angiogenesis, the development of new blood vessels, is an important process in tissue development and wound healing, but becomes pathologic when associated with solid tumor growth, proliferative retinopathies, and rheumatoid arthritis. accurate and reliable qualification of neovascular (angiogenic) response, both in vitro and in vivo, is an essential requirement for the study of new...

objective: angiogenesis a process that results in neo-vascularization is an essential stage in growth of solid tumors and the formation of metastases. vascular endothelial growth factor (vegf) and its receptors, vegfr1 (flt-1) and vegfr2 (kdr/flk-1), are the major regulators for tumor angiogenesis. recent studies showed that second domain of vegfr-1is a key factor for vegf/vegfr-1 interaction. ...